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Title

New Molecular Aspects of Cardiac Arrest; Promoting Cardiopulmonary Resuscitation Approaches

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  0-0

Abstract

 Introduction: Cardiopulmonary Resuscitation (CPR) is a method to improve survival of patients with Cardiac Arrest. This study aimed to identify the key genes affected five minutes after Cardiac Arrest, hoping to elevate the efficacy of CPR. Methods: In this bioinformatics study differentially expressed genes of six pigswere downloaded from GEO and screened. The significant and characterized genes were analyzed via calculating fold change and protein-protein interaction (PPI) networks. The crucial nodes were determined based on centrality parameters and their related biological processes were investigated via ClueGO. Results: 17 significant up-regulated (LogFC ¸ 2) and 22 down-regulated (LogFC <-0. 5) genes were detected. Transthyretin (TTR logFC = 4. 59) and Gonadotropin-releasing hormone receptor (GNRHR logFC = 3. 84) had higher logFC among up-regulated and down-regulated genes, respectively. The critical genes including four up-regulated and five down-regulated genes were detected from network analysis. GNRHR and Prolactin precursor (PRL) were among the most important down res 5 minutes after Cardiac Arrest and Beta-2 adrenergic receptor and Cadherin-1 were among the most important up regulated gens. Conclusion: The introduced potential Biomarkers could reveal a new molecular aspect for CPR performance and pituitary gland protection was highlighted in this respect.

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    APA: Copy

    ZAMANIAN AZODI, MONA, REZAEI TAVIRANI, MOSTAFA, ROSTAMI NEJAD, MOHAMMAD, & Tajik Rostami, Fatemeh. (2018). New Molecular Aspects of Cardiac Arrest; Promoting Cardiopulmonary Resuscitation Approaches. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 6(1), 0-0. SID. https://sid.ir/paper/339648/en

    Vancouver: Copy

    ZAMANIAN AZODI MONA, REZAEI TAVIRANI MOSTAFA, ROSTAMI NEJAD MOHAMMAD, Tajik Rostami Fatemeh. New Molecular Aspects of Cardiac Arrest; Promoting Cardiopulmonary Resuscitation Approaches. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2018;6(1):0-0. Available from: https://sid.ir/paper/339648/en

    IEEE: Copy

    MONA ZAMANIAN AZODI, MOSTAFA REZAEI TAVIRANI, MOHAMMAD ROSTAMI NEJAD, and Fatemeh Tajik Rostami, “New Molecular Aspects of Cardiac Arrest; Promoting Cardiopulmonary Resuscitation Approaches,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 6, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/339648/en

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