URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AND CYSTATIN C IN EARLY DETECTION OF PEDIATRIC ACUTE KIDNEY INJURY, A DIAGNOSTIC ACCURACY STUDY

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ATAEI NEAMATOLLAH; AMELI SONBOL; YOUSEFIFARD MAHMOUD; ORAEI ALIREZA; ATAEI FATEMEH; BAZARGANI BEHNAZ; ABBASI ARASH; HOSSEINI MOSTAFA

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Journal: Archives of Academic Emergency Medicine Year:2018 | Volume:6 | Issue:1 Page(s): 0-0

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Title

URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AND CYSTATIN C IN EARLY DETECTION OF PEDIATRIC ACUTE KIDNEY INJURY, A DIAGNOSTIC ACCURACY STUDY

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Keywords

CYSTATIN C

LIPOCALIN-2

ACUTE KIDNEY INJURY

EARLY DIAGNOSIS

DIMENSIONAL MEASUREMENT ACCURACY

Abstract

Introduction: There is a controversy regarding accuracy of neutrophil gelatinase-associated lipocalin (NGAL) and CYSTATIN C in early detection of ACUTE KIDNEY INJURY (AKI). The present study aimed to compare the diagnostic value of two biomarkers in this regard.Methods: In the present diagnostic accuracy study, all children between the ages of 1 month to 14 years were entered. Pediatric Risk, Injury Failure, Loss, End-stage renal disease (pRIFLE) criteria was used for identification of children with AKI as the reference test. Blood samples were taken from all patients at baseline and 48 hours after admission to assess serum creatinine and CYSTATIN C level. In addition, a urine sample was obtained within 6 hours of admission in order to measure NGAL level. In the end, area under the receiving operating characteristics (ROC) curve, sensitivity, and specificity of urine NGAL (uNGAL) and CYSTATIN C in early detection of AKI were compared.Results: Data from96 children with the mean age of 27.31±36.24 months were entered (56.25% girls). Area under the ROC curve of uNGAL level in diagnosis of AKI in children was 0.91 (95% CI: 0.80 to 1.00) and area under the ROC of CYSTATIN C was 0.90 (95% CI: 0.77 to 1.00). Both tests had the same value in diagnosis of AKI (p=0.89). The best cut-off point of uNGAL for diagnosing AKI was 125 mg/L. uNGAL had a sensitivity and specificity of 0.92 (0.62 to 0.99) and 0.69 (0.57 to 0.78), respectively. The best cut-off point of serum CYSTATIN C level was 0.4 mg/L. CYSTATIN C had a sensitivity and specificity of 0.92 (0.62 to 0.99) and 0.64 (0.52 to 0.74), respectively.Conclusion: The present study showed that uNGAL level has the same value as serum CYSTATIN C level in EARLY DIAGNOSIS of AKI.

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APA: Copy

ATAEI, NEAMATOLLAH, AMELI, SONBOL, YOUSEFIFARD, MAHMOUD, ORAEI, ALIREZA, ATAEI, FATEMEH, BAZARGANI, BEHNAZ, ABBASI, ARASH, & HOSSEINI, MOSTAFA. (2018). URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AND CYSTATIN C IN EARLY DETECTION OF PEDIATRIC ACUTE KIDNEY INJURY, A DIAGNOSTIC ACCURACY STUDY. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 6(1), 0-0. SID. https://sid.ir/paper/339656/en

Vancouver: Copy

ATAEI NEAMATOLLAH, AMELI SONBOL, YOUSEFIFARD MAHMOUD, ORAEI ALIREZA, ATAEI FATEMEH, BAZARGANI BEHNAZ, ABBASI ARASH, HOSSEINI MOSTAFA. URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AND CYSTATIN C IN EARLY DETECTION OF PEDIATRIC ACUTE KIDNEY INJURY, A DIAGNOSTIC ACCURACY STUDY. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2018;6(1):0-0. Available from: https://sid.ir/paper/339656/en

IEEE: Copy

NEAMATOLLAH ATAEI, SONBOL AMELI, MAHMOUD YOUSEFIFARD, ALIREZA ORAEI, FATEMEH ATAEI, BEHNAZ BAZARGANI, ARASH ABBASI, and MOSTAFA HOSSEINI, “URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AND CYSTATIN C IN EARLY DETECTION OF PEDIATRIC ACUTE KIDNEY INJURY, A DIAGNOSTIC ACCURACY STUDY,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 6, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/339656/en

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