Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

312
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

130
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Burn-induced Oxidative Stress and Serum Glutathione Depletion; a Cross Sectional Study

Pages

  0-0

Abstract

 Introduction: Several studies have shown the role of Oxidative stress in pathophysiology of burn injuries. This study aimed to evaluate the changes of oxidant-antioxidant levels during theweek following burn injuries and its correlation with grade of burn. Methods: In this prospective cross-sectional study, changes of total Glutathione, reduced Glutathione (GSH), oxidized GSH (GSSG), GSH/GSSG ratio, as well as Pro-oxidant-antioxidant balance (PAB) were investigated on the 1st, 2nd and 7th days of admission in patients with > 15% Burns. Results: 40 patients with the mean age of 21. 1 § 14. 5 were studied (47. 5% male). More than 50% of patients were in the 18 – 55 years age range and over 70% had 20% – 60% grade of burn. Total serum Glutathione level and GSH had significant decreasing trends (P < 0. 001) and GSSG and GSH/GSSG ratio had increasing trends (p < 0. 001). No significant correlation was observed between serum GSH level and the total body surface area (TBSA) of burn injury (r = 0. 047; p = 0. 779). The evaluation of PAB and its correlation with TBSA showed a significant and direct association between them on the 1st (coefficient = 0. 516; p = 0. 001), 2nd (coefficient = 0. 62; p <0. 001), and 3rd (coefficient = 0. 471; p = 0. 002) day of follow up. Conclusion: According to this study, the redox perturbation occurred in burn injurywhichwas measured and proved by decreased GSH/GSSG ratio aswell as the shift of PAB in favour of oxidants. Besides, since PAB positively correlated with the severity of dermal damage, itmight suggest the application of antioxidants as a part of therapeutic protocol for which the dosage should be proportionate to the surface area of the damaged skin.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    BEIRAGHI TOOSI, ARASH, Askarian, Roya, Sadrabadi Haghighi, Faezeh, SAFARIAN, MOHAMMAD, Kalantari, Fereshteh, & HASHEMY, SEYED ISAAC. (2018). Burn-induced Oxidative Stress and Serum Glutathione Depletion; a Cross Sectional Study. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 6(1), 0-0. SID. https://sid.ir/paper/339661/en

    Vancouver: Copy

    BEIRAGHI TOOSI ARASH, Askarian Roya, Sadrabadi Haghighi Faezeh, SAFARIAN MOHAMMAD, Kalantari Fereshteh, HASHEMY SEYED ISAAC. Burn-induced Oxidative Stress and Serum Glutathione Depletion; a Cross Sectional Study. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2018;6(1):0-0. Available from: https://sid.ir/paper/339661/en

    IEEE: Copy

    ARASH BEIRAGHI TOOSI, Roya Askarian, Faezeh Sadrabadi Haghighi, MOHAMMAD SAFARIAN, Fereshteh Kalantari, and SEYED ISAAC HASHEMY, “Burn-induced Oxidative Stress and Serum Glutathione Depletion; a Cross Sectional Study,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 6, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/339661/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top