Acute Lidocaine Toxicity; a Case Series

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RAHIMI MITRA; Elmi Mahboubeh; HASSANIAN MOGHADDAM HOSSEIN; ZAMANI NASIM; SOLTANINEJAD KAMBIZ; Forouzanfar Reza; SHADNIA SHAHIN

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Journal: Archives of Academic Emergency Medicine Year:2018 | Volume:6 | Issue:1 Page(s): 0-0

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Title

Acute Lidocaine Toxicity; a Case Series

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Keywords

Lidocaine

poisoning

drug-related side effects and adverse reactions

administration

Abstract

Introduction: Parenteral form of Lidocaine is the best-known source of Lidocaine poisoning. This study aimed to evaluate the characteristics of acute Lidocaine toxicity. Methods: In this retrospective cross-sectional study, demographics, clinical presentation, laboratory findings, and outcome of patients intoxicated with Lidocaine (based on ICD10 codes) admitted to Loghman HakimHospital, during April 2007 toMarch 2014 were analyzed. Results: 30 cases with the mean age of 21. 83 § 6. 57 year were studied (60% male). All subjects had used either 6. 5% Lidocaine spray or 2% topical formulations of Lidocaine. The mean consumed dose of Lidocaine was 465 § 318. 17 milligrams. The most frequent clinical presentations were nausea and vomiting (50%), seizure (33. 3%), and loss of consciousness (16. 7%). 22 (73. 3%) cases had normal sinus rhythm, 4 (13. 3%) bradycardia, 2 (6. 7%) ventricular tachycardia, and 2 (6. 7%) had left axis deviation. 11 (36. 6%) cases were intubated and admitted to intensive care unit (ICU) for 6. 91 § 7. 16 days. Three patients experienced status epilepticus that led to cardiac arrest, and death (all cases with suicidal intention). Conclusion: Based on the results of this study, most cases of topical Lidocaine toxicity were among < 40-year-old patients with a male to female ratio of 1. 2, with suicidal attempt in 90%, need for intensive care in 36. 6%, and mortality rate of 10%.

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APA: Copy

RAHIMI, MITRA, Elmi, Mahboubeh, HASSANIAN MOGHADDAM, HOSSEIN, ZAMANI, NASIM, SOLTANINEJAD, KAMBIZ, Forouzanfar, Reza, & SHADNIA, SHAHIN. (2018). Acute Lidocaine Toxicity; a Case Series. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 6(1), 0-0. SID. https://sid.ir/paper/339682/en

Vancouver: Copy

RAHIMI MITRA, Elmi Mahboubeh, HASSANIAN MOGHADDAM HOSSEIN, ZAMANI NASIM, SOLTANINEJAD KAMBIZ, Forouzanfar Reza, SHADNIA SHAHIN. Acute Lidocaine Toxicity; a Case Series. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2018;6(1):0-0. Available from: https://sid.ir/paper/339682/en

IEEE: Copy

MITRA RAHIMI, Mahboubeh Elmi, HOSSEIN HASSANIAN MOGHADDAM, NASIM ZAMANI, KAMBIZ SOLTANINEJAD, Reza Forouzanfar, and SHAHIN SHADNIA, “Acute Lidocaine Toxicity; a Case Series,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 6, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/339682/en

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