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Title

Serum and Cerebrospinal Fluid Levels of S-100¯ Is A Biomarker for Spinal Cord Injury; a Systematic Review andMeta-Analysis

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Abstract

 Introduction: There is controversy regarding the value of serum or cerebrospinal fluid (CSF) levels of S100 calcium-binding protein B (S-100¯ ) in spinal cord injury (SCI). For reaching a general conclusion, the present meta-analysis was designed aiming to evaluate the value of serumand CSF levels of S-100¯ protein in detecting the presence of SCI in animal studies. Methods: An extensive search was performed inMedline, Embase, Scopus andWeb of science databases. Screening articles, summarizing them and entering data to checklist and quality assessment of the mentioned articles were done by 2 independent reviewers. Data were analyzed and a pooled standardized mean difference (SMD) and 95% confidence interval (95% CI) were presented. Results: Finally, the data of 7 articles were included in the meta-analysis. Serumlevel of S-100B had increased as a result of SCI. During the first 6 hours after injury, the level of this proteinwas very high (SMD=3. 8; 95%CI: 2. 6 to 5. 1; p<0. 0001), but as time passed the serum level of the protein had decreased (SMD=0. 4; 95% CI:-1. 2 to 2. 0; p=0. 65). In addition, CSF level of the mentioned protein was very high during the initial 6 hours after injury (SMD: 5. 8; 95% CI: 3. 6 to 8. 0), and this elevated level was still observed until 12 hours after injury (SMD: 6. 5; 95% CI: 3. 7 to 9. 3; p<0. 0001). Conclusion: The results of the present systematic review and meta-analysis show that measuring the level of S-100¯ protein in serum and CSF has a potential value in diagnosis of SCI in animal models. This biomarker increases during the initial 6 hours following injury and remains high until 24 hours after that. However, more than 24 hours after the injury, serum level of this protein returns to the level of Animals without SCI.

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    APA: Copy

    FARIDAALAEE, GHOLAMREZA, & KEYGHOBADI KHAJEH, FATEMEH. (2019). Serum and Cerebrospinal Fluid Levels of S-100¯ Is A Biomarker for Spinal Cord Injury; a Systematic Review andMeta-Analysis. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 7(1), 0-0. SID. https://sid.ir/paper/339785/en

    Vancouver: Copy

    FARIDAALAEE GHOLAMREZA, KEYGHOBADI KHAJEH FATEMEH. Serum and Cerebrospinal Fluid Levels of S-100¯ Is A Biomarker for Spinal Cord Injury; a Systematic Review andMeta-Analysis. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2019;7(1):0-0. Available from: https://sid.ir/paper/339785/en

    IEEE: Copy

    GHOLAMREZA FARIDAALAEE, and FATEMEH KEYGHOBADI KHAJEH, “Serum and Cerebrospinal Fluid Levels of S-100¯ Is A Biomarker for Spinal Cord Injury; a Systematic Review andMeta-Analysis,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 7, no. 1, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/339785/en

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