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Title

Association of Lymphopenia with Short TermOutcomes of Sepsis Patients; a Brief Report

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Abstract

 Introduction: Studies have claimed that low lymphocyte count is independently correlated with 28-day survival of sepsis patients. Therefore, this study aimed to evaluate the value of Lymphopenia in predicting the short-term outcome of sepsis patients. Methods: This cross-sectional study was performed on sepsis patients referred to the emergency department during an 8-month period and relationship of Lymphopenia with 28-day mortality and probability of septic shock and readmission due to sepsis was assessed. Results: 124 cases with the mean age of 66. 12 § 15. 82 (21-90) years were studied (54. 8% male). 81 (65. 3%) cases had Lymphopenia (59. 3% male). Lymphopenic patients had a significantly higher mean age (p = 0. 003), higher need for ICU admission (p < 0. 001), higher prevalence of 28-day septic shock (p < 0. 001), higher 28-day mortality (p < 0. 001), higher probability of readmission due to sepsis (p = 0. 048), and higher SOFA score (p < 0. 001). During 28 days of follow up, 57 (46%) patients were expired. They had a higher prevalence of septic shock (p < 0. 001) and higher SOFA score (p < 0. 001). Multivariate analysis showed that septic shock (OR=364. 6; 95% CI: 26. 3 to 5051. 7; p = 0. 001) and Lymphopenia (OR=19. 2; 95% CI: 1. 7 to 211. 3; p = 0. 016) were the independent predictors of 28-day mortality. Conclusion: Based on the findings, Lymphopenia was independently associated with higher 28-day mortality and lymphopenic patients were older than the control group and had a significantly higher need for ICU admission, higher probability of 28-day septic shock and readmission due to sepsis, and higher SOFA score.

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    APA: Copy

    Sheikh Motahar Vahedi, Hojat, BAGHERI, AIDA, JAHANSHIR, AMIRHOSEIN, SEYEDHOSSEINI, JAVAD, & VAHIDI, ELNAZ. (2019). Association of Lymphopenia with Short TermOutcomes of Sepsis Patients; a Brief Report. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 7(1), 0-0. SID. https://sid.ir/paper/339830/en

    Vancouver: Copy

    Sheikh Motahar Vahedi Hojat, BAGHERI AIDA, JAHANSHIR AMIRHOSEIN, SEYEDHOSSEINI JAVAD, VAHIDI ELNAZ. Association of Lymphopenia with Short TermOutcomes of Sepsis Patients; a Brief Report. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2019;7(1):0-0. Available from: https://sid.ir/paper/339830/en

    IEEE: Copy

    Hojat Sheikh Motahar Vahedi, AIDA BAGHERI, AMIRHOSEIN JAHANSHIR, JAVAD SEYEDHOSSEINI, and ELNAZ VAHIDI, “Association of Lymphopenia with Short TermOutcomes of Sepsis Patients; a Brief Report,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 7, no. 1, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/339830/en

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