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Information Journal Paper

Title

Proteomic Analysis of patients with Epileptic Seizure and Psychogenic Non-epileptic Seizure; a Cross-Sectional Study

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Abstract

 Introduction: There is an increasing interest in the use of different biomarkers to help distinguish psychogenic non-epileptic seizure (PNES) fromepileptic Seizures (ES). This study aimed to evaluate the patterns of differentially expressed serum proteins in ES and PNES cases. Methods: In this cross-sectional study, 4 patients with mesial temporal lobe epilepsy and 4 patients with PNES were selected from patients with history of recurrent Seizures. Venous blood samples were obtained within 1 hour after seizure and serum proteomes as well as the extent of protein expression were analyzed. Results: 361 proteins were identified; of these, expression of 197 proteins had altered. 110 (55. 9%) proteins were down-regulated and 87 (44. 1%) were up-regulated in the PNES samples compared to ES samples. The mean pI for deregulated proteins with 1. 5 to 3 fold changes were 6. 69 § 1. 68 in proteins with increasing expression in ES group and 5. 88 § 1. 39 in proteins with increasing expression in PNES group (p = 0. 008). The median and interquartile range (IQR) of molecular weight changes in proteins with 1. 5 to 3 fold changes were 64 (22. 0-86. 0) in proteins whose expression had increased in ES group and 39. 5 (26. 0-61. 5) in proteins whose expression had increased in PNES cases (p = 0. 05). Conclusion: Several spots with differential expression were observed by comparing patients with ES against the PNES groups, which could be potential biomarkers of the disease. Damage to the blood-brain barrier is the most important difference between the two groups, thus identifying total protein changes offers a key to the future of differentiating ES and PNES patients.

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    APA: Copy

    PARVARESHI HAMRAH, MOHSEN, REZAEI TAVIRANI, MOSTAFA, MOVAHEDI, MONIREH, & Ahmadi Karvigh, Sanaz. (2020). Proteomic Analysis of patients with Epileptic Seizure and Psychogenic Non-epileptic Seizure; a Cross-Sectional Study. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 8(1), 0-0. SID. https://sid.ir/paper/339880/en

    Vancouver: Copy

    PARVARESHI HAMRAH MOHSEN, REZAEI TAVIRANI MOSTAFA, MOVAHEDI MONIREH, Ahmadi Karvigh Sanaz. Proteomic Analysis of patients with Epileptic Seizure and Psychogenic Non-epileptic Seizure; a Cross-Sectional Study. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2020;8(1):0-0. Available from: https://sid.ir/paper/339880/en

    IEEE: Copy

    MOHSEN PARVARESHI HAMRAH, MOSTAFA REZAEI TAVIRANI, MONIREH MOVAHEDI, and Sanaz Ahmadi Karvigh, “Proteomic Analysis of patients with Epileptic Seizure and Psychogenic Non-epileptic Seizure; a Cross-Sectional Study,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 8, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/339880/en

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