مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

339
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

185
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

SEMIPROTECTIVE EFFECTS OF HEMPSEED OIL ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN MALE RATS: AN ULTRA-SHORT TOXICOLOGICAL INTERVENTION

Author(s)

 HASHEMZADEH MONA | MOGHADDAM ALIASGHAR | KARIMI ISAAC | MINOOSH SIAVOSH HAGHIGHI ZAHRA | HASSANPOUR SHAHIN | Issue Writer Certificate 

Pages

  319-329

Abstract

 This study was designed to investigate the protective activity of HEMPSEED oil on CARBON TETRACHLORIDE (CCl4) hepatotoxicity in male RATs at Islamic Azad University, Saveh Branch, Saveh, Iran in 2015. Normal control (NC) group was injected intraperitoneally (i.p.) with distilled water (0.5 ml/kg); CCl4-intoxicated group (TCC) injected CCl4; HEMPSEED oil treated group (HSO) gavaged HEMPSEED oil; TCC-HSO group was injected CCl4 prior to intake of HEMPSEED oil and HSO-TCC group was gavaged HEMPSEED oil prior to being injected with CCl4. In all treated groups, toxicity was induced by i.p. injection of CCl4 (0.5 ml/kg) for two consecutive days and hemp seed, oil was gavaged at 8 ml/kg in respective group once daily for one week. Plasma alanine aminotransferase (ALT) and aspartate transaminase (AST) levels increased in TCC. Protection against toxicity in HSO-TCC and TCC-HSO reduced AST and ALT activities compared to TCC. Plasma alkaline phosphatase activity in TCC-HSO and HSO-TCC increased as compared with other groups. CCl4 decreased plasma high-density LIPOPROTEIN cholesterol (HDL-C) in TCC. HEMPSEED oil decreased total cholesterol (TC), low-density LIPOPROTEIN cholesterol (LDL-C), very low-density LIPOPROTEIN cholesterol, and triacylglycerols in HSO compared to NC. HEMPSEED oil in TCC-HSO and HSO-TCC restored TC, HDL-C, and LDL-C levels to those of NC. Atherogenic index was lower in HSO in comparison to TCC. Based on histopathology, HEMPSEED oil improved CCl4-induced-cardio- and hepatotoxicity in TCC-HSO and HSO-TCC; however, HEMPSEED oil did not prevent CCl4-induced nephrotoxicity. To sum up, HEMPSEED oil has mild protective effects against CCl4 toxicity in male RATs.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    HASHEMZADEH, MONA, MOGHADDAM, ALIASGHAR, KARIMI, ISAAC, MINOOSH SIAVOSH HAGHIGHI, ZAHRA, & HASSANPOUR, SHAHIN. (2017). SEMIPROTECTIVE EFFECTS OF HEMPSEED OIL ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN MALE RATS: AN ULTRA-SHORT TOXICOLOGICAL INTERVENTION. JOURNAL OF CHEMICAL HEALTH RISKS (JCHR), 7(4), 319-329. SID. https://sid.ir/paper/340344/en

    Vancouver: Copy

    HASHEMZADEH MONA, MOGHADDAM ALIASGHAR, KARIMI ISAAC, MINOOSH SIAVOSH HAGHIGHI ZAHRA, HASSANPOUR SHAHIN. SEMIPROTECTIVE EFFECTS OF HEMPSEED OIL ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN MALE RATS: AN ULTRA-SHORT TOXICOLOGICAL INTERVENTION. JOURNAL OF CHEMICAL HEALTH RISKS (JCHR)[Internet]. 2017;7(4):319-329. Available from: https://sid.ir/paper/340344/en

    IEEE: Copy

    MONA HASHEMZADEH, ALIASGHAR MOGHADDAM, ISAAC KARIMI, ZAHRA MINOOSH SIAVOSH HAGHIGHI, and SHAHIN HASSANPOUR, “SEMIPROTECTIVE EFFECTS OF HEMPSEED OIL ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN MALE RATS: AN ULTRA-SHORT TOXICOLOGICAL INTERVENTION,” JOURNAL OF CHEMICAL HEALTH RISKS (JCHR), vol. 7, no. 4, pp. 319–329, 2017, [Online]. Available: https://sid.ir/paper/340344/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button