EFFECTS OF CIPROFLOXACIN ON RAT SERTOLI CELLS

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KHAKI ARASH; BAZI P.; GHAFARI NOVIN M.

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Journal: IRANIAN SOUTH MEDICAL JOURNAL (ISMJ) Year:2006 | Volume:8 | Issue:2 Page(s): 110-118

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Title

EFFECTS OF CIPROFLOXACIN ON RAT SERTOLI CELLS

Author(s)

KHAKI ARASH | BAZI P. | GHAFARI NOVIN M. | Issue Writer Certificate

Keywords

CIPROFLOXACINQ3

SERTOLI CELLSQ4

TESTISQ2

RATQ2

Abstract

Background: CIPROFLOXACIN is a synthetic antibacterial agent from the fluoroquinolones family with a very broad spectrum against microbial pathogens, especially Gram-negative infectious diseases, which has been approved in more than 100 countries world-wide. This study was planed to identify the histopathological effects of CIPROFLOXACIN on RAT SERTOLI CELLS. Methods: Twenty male Wistar RATs were selected and randomly divided into two groups; control (n=10) and experimental (n=10). The experimental group received 12.5 mg/kg oral CIPROFLOXACIN daily for sixty days. On sixtieth day the TESTIS tissues in both groups were removed and weighted, then prepared for light microscopy and electron microscopy studies. Results: There was a marked decrease in testicular weight, marked accumulation and atrophy of seminiferous tubules of SERTOLI CELLS in experimental group as compared with control group (P<0.05). Conclusion: CIPROFLOXACIN can induce marked histological alteration in testicular tissue of RAT, therefore these histological effects and possibility of producing infertility should be investigated in human subjects.

Cites

References

SURVEY THE EFFECTS OF CIPROFLOXACIN ON RAT TESTIS TISSUE CONSIDERING ELECTRON MICROSCOPY

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APA: Copy

KHAKI, ARASH, BAZI, P., & GHAFARI NOVIN, M.. (2006). EFFECTS OF CIPROFLOXACIN ON RAT SERTOLI CELLS. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 8(2), 110-118. SID. https://sid.ir/paper/34058/en

Vancouver: Copy

KHAKI ARASH, BAZI P., GHAFARI NOVIN M.. EFFECTS OF CIPROFLOXACIN ON RAT SERTOLI CELLS. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2006;8(2):110-118. Available from: https://sid.ir/paper/34058/en

IEEE: Copy

ARASH KHAKI, P. BAZI, and M. GHAFARI NOVIN, “EFFECTS OF CIPROFLOXACIN ON RAT SERTOLI CELLS,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 8, no. 2, pp. 110–118, 2006, [Online]. Available: https://sid.ir/paper/34058/en

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