SURVEY OF INDUCED APOPTOSIS EFFECT OF CIPROFLOXACIN IN RAT'S TESTIS BY TUNEL TECHNIQUE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHAKI AMIR AFSHIN; GHAFARI NOVIN M.; EBRAHIM NEZHAD A.A.; KHAKI A.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES Year:2007 | Volume:16 | Issue:61 Page(s): 22-29

Download Full-Text

Persian Verion

View:

918

Download:

Cites:

Information Journal Paper

Title

SURVEY OF INDUCED APOPTOSIS EFFECT OF CIPROFLOXACIN IN RAT'S TESTIS BY TUNEL TECHNIQUE

Author(s)

KHAKI AMIR AFSHIN | GHAFARI NOVIN M. | EBRAHIM NEZHAD A.A. | KHAKI A.A. | Issue Writer Certificate

Keywords

APOPTOSISQ3

CIPROFLOXACINQ2

RATQ3

TESTISQ2

Abstract

Introduction: CIPROFLOXACIN is a synthetic antibacterial agent belonging to the family of fluoroquinolones that has a very broad spectrum against of microbial pathogens, especially Gram-negative infectious diseases, which has been approved in more than 100 countries in world. Objective: The aim of this study was planed to see APOPTOSIS effects of CIPROFLOXACIN after inducement, in RAT TESTIS. Materials and Methods: The twenty male wistar RAT were selected and divided randomly into two groups; control (n=10) and experimental (n=10). The test group was received 12.5mg/kg (PO) CIPROFLOXACIN daily for sixty days, in their drinking water however the control group just received its routine drinking water. On sixtieth day the TESTIS tissue of RATs in both groups were removed in 10% formalin solution and prepared for light microscopy, and the Terminal Uridine Nick End Labeling (TUNEL) technique was used to identify APOPTOSIS. Results: Light microscopic studies showed apoptotic bodies in tissue of TESTIS in experimental group were (15.15±10.17) and were(3±2.41) in control group, This difference in apoptotic bodies in experimental and control groups was significant (P<0.01). Conclusion: Since in our study CIPROFLOXACIN had side effect such as increasing apoptotic body in TESTIS cells in RAT in experimental group, then it was suggested that CIPROFLOXACIN using in human could induced many histopathogical disorders and might be decreased the fertility RAT.

Cites

References

Cite

APA: Copy

KHAKI, AMIR AFSHIN, GHAFARI NOVIN, M., EBRAHIM NEZHAD, A.A., & KHAKI, A.A.. (2007). SURVEY OF INDUCED APOPTOSIS EFFECT OF CIPROFLOXACIN IN RAT'S TESTIS BY TUNEL TECHNIQUE. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 16(61), 22-29. SID. https://sid.ir/paper/39719/en

Vancouver: Copy

KHAKI AMIR AFSHIN, GHAFARI NOVIN M., EBRAHIM NEZHAD A.A., KHAKI A.A.. SURVEY OF INDUCED APOPTOSIS EFFECT OF CIPROFLOXACIN IN RAT'S TESTIS BY TUNEL TECHNIQUE. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;16(61):22-29. Available from: https://sid.ir/paper/39719/en

IEEE: Copy

AMIR AFSHIN KHAKI, M. GHAFARI NOVIN, A.A. EBRAHIM NEZHAD, and A.A. KHAKI, “SURVEY OF INDUCED APOPTOSIS EFFECT OF CIPROFLOXACIN IN RAT'S TESTIS BY TUNEL TECHNIQUE,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 61, pp. 22–29, 2007, [Online]. Available: https://sid.ir/paper/39719/en

Related Journal Papers