ROLE OF S-METHYLISOTHIOUREA (SMT) IN RENAL ISCHEMIA/REPERFUSION INJURY IN RATS

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KANANI FATEMEH; FAZELNIA FAEZEH; MOJARRADFARD MOHADDESEH; NEMATBAKHSH MEHDI; MOSLEMI FATEMEH; ESHRAGHI JAZI FATEMEH; TALEBI ARDESHIR

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Journal: JOURNAL OF RENAL INJURY PREVENTION Year:2016 | Volume:5 | Issue:1 Page(s): 29-33

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Title

ROLE OF S-METHYLISOTHIOUREA (SMT) IN RENAL ISCHEMIA/REPERFUSION INJURY IN RATS

Author(s)

Keywords

RENAL ISCHEMIA REPERFUSION

S-METHYLISOTHIOUREA

RENAL INJURY

NITRIC OXIDE

Abstract

Introduction: Excessive production of NITRIC OXIDE (NO) via inducible NITRIC OXIDE synthase (iNOS) is associated in RENAL ISCHEMIA REPERFUSION injury (IRI).Objectives: This study was designed to investigate the role of S-METHYLISOTHIOUREA (SMT) as selective inhibitor iNOS in renal IRI.Materials and Methods: Male Wistar rats were subjected to 45 minutes of bilateral renal ischemia by occlusion of renal vessels of both kidney followed by 24 hours of reperfusion. Prior to renal IRI, the rats received either vehicle (saline, group 2) or SMT (50 mg/kg, group 3), and were compared with the sham-operated animals (group 1). At the end of reperfusion period, the rats were sacrificed for kidney tissue pathology investigation.Results: Serum creatinine (Cr), blood urea nitrogen (BUN), nitrite levels, and kidney weight significantly increased in groups 2 and 3 (P<0.05). Kidney tissue damage scores in groups 2 and 3 were also higher than that in the sham-operated group (P<0.05).Conclusion: SMT not only prevent the kidney during IRI, but also promotes kidney function disturbance and severity of RENAL INJURY.

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APA: Copy

KANANI, FATEMEH, FAZELNIA, FAEZEH, MOJARRADFARD, MOHADDESEH, NEMATBAKHSH, MEHDI, MOSLEMI, FATEMEH, ESHRAGHI JAZI, FATEMEH, & TALEBI, ARDESHIR. (2016). ROLE OF S-METHYLISOTHIOUREA (SMT) IN RENAL ISCHEMIA/REPERFUSION INJURY IN RATS. JOURNAL OF RENAL INJURY PREVENTION, 5(1), 29-33. SID. https://sid.ir/paper/341021/en

Vancouver: Copy

KANANI FATEMEH, FAZELNIA FAEZEH, MOJARRADFARD MOHADDESEH, NEMATBAKHSH MEHDI, MOSLEMI FATEMEH, ESHRAGHI JAZI FATEMEH, TALEBI ARDESHIR. ROLE OF S-METHYLISOTHIOUREA (SMT) IN RENAL ISCHEMIA/REPERFUSION INJURY IN RATS. JOURNAL OF RENAL INJURY PREVENTION[Internet]. 2016;5(1):29-33. Available from: https://sid.ir/paper/341021/en

IEEE: Copy

FATEMEH KANANI, FAEZEH FAZELNIA, MOHADDESEH MOJARRADFARD, MEHDI NEMATBAKHSH, FATEMEH MOSLEMI, FATEMEH ESHRAGHI JAZI, and ARDESHIR TALEBI, “ROLE OF S-METHYLISOTHIOUREA (SMT) IN RENAL ISCHEMIA/REPERFUSION INJURY IN RATS,” JOURNAL OF RENAL INJURY PREVENTION, vol. 5, no. 1, pp. 29–33, 2016, [Online]. Available: https://sid.ir/paper/341021/en

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