مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EPIGENETIC DIABETIC VASCULAR COMPLICATIONS

Pages

  0-0

Abstract

 Diabetic VASCULAR COMPLICATIONS (DVC) influence several vital organ systems including cardiovascular, renal, ocular and nervous systems making it a major public health problem. Although extensive researches were performed in this field, the exact mechanisms responsible for these organ damages in diabetes remain obscure. Several metabolic disturbances have been involved in its complication and change in genes associated with these pathways occurred. Gene expression to produce a biologically active protein can be controlled by transcriptional and translational alteration on the head of genes without change in nucleotide composition. These EPIGENETIC adjustments are steady, but possibly reversible and can be transmitted to future generation. Gene expression can be regulated by three EPIGENETIC mechanisms including DNA methylation, histone modifications and noncoding microRNAs (miRNAs) activity. EPIGENETIC studies must be directed to better realize the role of EPIGENETIC changes to the etiology of DVC and knowledge of EPIGENETIC would play a pivotal role in the application of individualized medicine. Application and development of high technology sequencing combined with more sensitive and advanced methodologies for epigenome studying help to determine specific EPIGENETIC events that stimulate gene responses in patients with DIABETES MELLITUS.

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    • Cite

    APA: Copy

    AHMADZADEH AMIRI, ALI, & AHMADZADEH AMIRI, AHMAD. (2016). EPIGENETIC DIABETIC VASCULAR COMPLICATIONS. JOURNAL OF PEDIATRICS REVIEW, 4(1), 0-0. SID. https://sid.ir/paper/341190/en

    Vancouver: Copy

    AHMADZADEH AMIRI ALI, AHMADZADEH AMIRI AHMAD. EPIGENETIC DIABETIC VASCULAR COMPLICATIONS. JOURNAL OF PEDIATRICS REVIEW[Internet]. 2016;4(1):0-0. Available from: https://sid.ir/paper/341190/en

    IEEE: Copy

    ALI AHMADZADEH AMIRI, and AHMAD AHMADZADEH AMIRI, “EPIGENETIC DIABETIC VASCULAR COMPLICATIONS,” JOURNAL OF PEDIATRICS REVIEW, vol. 4, no. 1, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/341190/en

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