SYNTHESIS, LABELING, FORMULATION AND QUALITY CONTROL OF 99MTC-TRICINE-HYNIC-TYR³-OCTREOTIDE, A PEPTIDE RADIOPHARMACEUTICAL FOR IMAGING SOMATOSTATIN RECEPTOR POSITIVE TUMORS

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GANDOMKAR M.; NAJAFI R.; SADAT EBRAHIMI S.E.; SHAFIEI A.; BABAEI M.H.; RABANI M.; SHABANI G.A.

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Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2003 | Volume:- | Issue:19 Page(s): 23-28

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Title

SYNTHESIS, LABELING, FORMULATION AND QUALITY CONTROL OF 99MTC-TRICINE-HYNIC-TYR³-OCTREOTIDE, A PEPTIDE RADIOPHARMACEUTICAL FOR IMAGING SOMATOSTATIN RECEPTOR POSITIVE TUMORS

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Keywords

SOMATOSTATINQ3

TYR-OCTREOTIDEQ3

HYNICQ3

TRICINEQ3

99MTCQ3

Abstract

SOMATOSTATIN analogs labeled with different radionuclide are able used for imaging and treatment of SOMATOSTATIN receptor positive tumors. In this study Tyr³-Octreotide protected at lysine as an analoge of SOMATOSTATIN was conjugated with bifunctional chelating agent 6-BOC-hydrazinopyridine-3-carboxylic acid (BOC-HYNIC) and after deprotecting of conjugate, purification was performed with preparative-RP-HPLC. The conjugated peptide was labeled with 99MTC and TRICINE as coligand. Radiolabel ling efficiency, radiochemical purity, stability in human serum, internalization of receptor bound 99MTC-labeled peptide and biodistribution in normal mice were studied

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APA: Copy

GANDOMKAR, M., NAJAFI, R., SADAT EBRAHIMI, S.E., SHAFIEI, A., BABAEI, M.H., RABANI, M., & SHABANI, G.A.. (2003). SYNTHESIS, LABELING, FORMULATION AND QUALITY CONTROL OF 99MTC-TRICINE-HYNIC-TYR³-OCTREOTIDE, A PEPTIDE RADIOPHARMACEUTICAL FOR IMAGING SOMATOSTATIN RECEPTOR POSITIVE TUMORS. IRANIAN JOURNAL OF NUCLEAR MEDICINE, -(19), 23-28. SID. https://sid.ir/paper/34197/en

Vancouver: Copy

GANDOMKAR M., NAJAFI R., SADAT EBRAHIMI S.E., SHAFIEI A., BABAEI M.H., RABANI M., SHABANI G.A.. SYNTHESIS, LABELING, FORMULATION AND QUALITY CONTROL OF 99MTC-TRICINE-HYNIC-TYR³-OCTREOTIDE, A PEPTIDE RADIOPHARMACEUTICAL FOR IMAGING SOMATOSTATIN RECEPTOR POSITIVE TUMORS. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2003;-(19):23-28. Available from: https://sid.ir/paper/34197/en

IEEE: Copy

M. GANDOMKAR, R. NAJAFI, S.E. SADAT EBRAHIMI, A. SHAFIEI, M.H. BABAEI, M. RABANI, and G.A. SHABANI, “SYNTHESIS, LABELING, FORMULATION AND QUALITY CONTROL OF 99MTC-TRICINE-HYNIC-TYR³-OCTREOTIDE, A PEPTIDE RADIOPHARMACEUTICAL FOR IMAGING SOMATOSTATIN RECEPTOR POSITIVE TUMORS,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. -, no. 19, pp. 23–28, 2003, [Online]. Available: https://sid.ir/paper/34197/en

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