EVALUATION AND COMPARISON OF DIFFERENT QUALITY CONTROL METHODS IN RADIOCHEMICAL PURITY DETERMINATION OF NEW PEPTIDE KITS 99MTC- EDDA- TRICINE-HYNIC- TYR3-OCTREOTIDE AND 99MTC-EDDA-TRICINE- HYNIC- TYR3-OCTREOTATE FOR IMAGING SOMATOSTATIN RECEPTOR POSITIVE TUMORS

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GANDOMKAR M.; NAJAFI R.

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Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2006 | Volume:14 | Issue:26 Page(s): 28-34

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Title

EVALUATION AND COMPARISON OF DIFFERENT QUALITY CONTROL METHODS IN RADIOCHEMICAL PURITY DETERMINATION OF NEW PEPTIDE KITS 99MTC- EDDA- TRICINE-HYNIC- TYR3-OCTREOTIDE AND 99MTC-EDDA-TRICINE- HYNIC- TYR3-OCTREOTATE FOR IMAGING SOMATOSTATIN RECEPTOR POSITIVE TUMORS

Author(s)

GANDOMKAR M. | NAJAFI R. | Issue Writer Certificate

Keywords

99MTCQ1

TYR3-OCTREOTIDEQ1

TYR3-OCTREOTATEQ2

QUALITY CONTROLQ1

RADIOCHEMICAL PURITYQ1

Abstract

Introduction: Using labeled peptides enjoys high importance in nuclear medicine. Somatostatin analogs labeled with different radionuclide are vastly investigated for diagnosis or treatment of somatostatin receptor positive tumors. Labeling somatostatin analogs with 99mTcas alternative of 111 In needs doing different QUALITY CONTROL method for determination of labeling yield and complex stability for clinic applications.Methods: For determining RADIOCHEMICAL PURITY, three different methods were compared and evaluated including HPLC, TLC and Sep-Pak. Results: All the three methods were suitable for determining of RADIOCHEMICAL PURITY in peptide kits, although using HPLC was more effective rather than the others.Conclusion: HPLC was the best method for determination of RADIOCHEMICAL PURITY of the peptide kits. TLC or Sep-Pak method should only be employed if HPLC is not available in nuclear medicine clinics, and after training and gaining sufficient operational experience.

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APA: Copy

GANDOMKAR, M., & NAJAFI, R.. (2006). EVALUATION AND COMPARISON OF DIFFERENT QUALITY CONTROL METHODS IN RADIOCHEMICAL PURITY DETERMINATION OF NEW PEPTIDE KITS ^99MTC- EDDA- TRICINE-HYNIC- TYR³-OCTREOTIDE AND ^99MTC-EDDA-TRICINE- HYNIC- TYR³-OCTREOTATE FOR IMAGING SOMATOSTATIN RECEPTOR POSITIVE TUMORS. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 14(26), 28-34. SID. https://sid.ir/paper/34215/en

Vancouver: Copy

GANDOMKAR M., NAJAFI R.. EVALUATION AND COMPARISON OF DIFFERENT QUALITY CONTROL METHODS IN RADIOCHEMICAL PURITY DETERMINATION OF NEW PEPTIDE KITS ^99MTC- EDDA- TRICINE-HYNIC- TYR³-OCTREOTIDE AND ^99MTC-EDDA-TRICINE- HYNIC- TYR³-OCTREOTATE FOR IMAGING SOMATOSTATIN RECEPTOR POSITIVE TUMORS. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2006;14(26):28-34. Available from: https://sid.ir/paper/34215/en

IEEE: Copy

M. GANDOMKAR, and R. NAJAFI, “EVALUATION AND COMPARISON OF DIFFERENT QUALITY CONTROL METHODS IN RADIOCHEMICAL PURITY DETERMINATION OF NEW PEPTIDE KITS ^99MTC- EDDA- TRICINE-HYNIC- TYR³-OCTREOTIDE AND ^99MTC-EDDA-TRICINE- HYNIC- TYR³-OCTREOTATE FOR IMAGING SOMATOSTATIN RECEPTOR POSITIVE TUMORS,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 14, no. 26, pp. 28–34, 2006, [Online]. Available: https://sid.ir/paper/34215/en

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