EVALUATION OF DIOAGNOSTIC ROLE OF 99MTC-TETROFOSMIN SCINTIGRAPHY IN COLD THYROID NODULES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

EFTEKHARI MEHRDAD; SAGHARI M.; NOURANI M.H.; FARD ESFAHANI A.; FALAHI SICHANI B.; BEYKI D.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2005 | Volume:13 | Issue:24 Page(s): 25-30

Download Full-Text

Persian Verion

View:

2,023

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF DIOAGNOSTIC ROLE OF 99MTC-TETROFOSMIN SCINTIGRAPHY IN COLD THYROID NODULES

Author(s)

Keywords

99M TC-TETROFOSMINQ2

SCINTIGRAPHYQ1

MALIGNANCYQ2

COLD NODULE OF THYROIDQ2

Abstract

Introduction: Various radiopharmaceuticals, including 67Ga, 201Tl, and 99mTc-sestamibi have been used to differentiate benign from malignant thyroid nodules. 99mTc-Tetrofosmin, a lipophilic cationic radiotracer, and 99mTc-sestamibi have also been reported to accumulate in thyroid tumors. In this study, we evaluated the role of 99mTc-Tetrofosmin in the differentiation of malignant from benign thyroid nodules. Methods: We prospectively studied 108 patients with solitary cold thyroid nodule on 99mTcpertechnetate SCINTIGRAPHY (33 malignant and 75 benign) to investigate the diagnostic value of 99mTc-Tetrofosmin SCINTIGRAPHY. 99mTc-Tetrofosmin SCINTIGRAPHY was performed 15, 60, and 120 minutes following IV injection of 20 mCi (740 MBq) of radiotracer in the anterior planar mode with a gamma camera equipped with LEAP collimator. The scans were visually analyzed by two experienced nuclear physician. The nodules with late tracer retention (activity more than adjacent thyroid tissue) were classified as positive and nodules without late retention were interpreted as negative for MALIGNANCY. Fine needle aspiration (FNA) was performed in all patients in 3-7 days interval. 52 patients were subsequently operated on while 56 patients refused surgery. These 56 patients, however, had at least two negative FNA results. Results: 45 out of 108 nodules show high 99mTc-Tetrofosmin uptake on delayed images; 27 of them were malignant. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated to be 81.8%, 76.0%, 54.0%, and 90.4% respectively. Accuracy of the test was also determined to be 77.7%. Conclusion: We concluded that 99mTc-Tetrofosmin SCINTIGRAPHY is a relatively sensitive, but not enough specific, method in diagnosing malignant thyroid nodules. This agent could be of value in the presence of FNA limitations.

Cites

No record.

References

No record.

Cite

APA: Copy

EFTEKHARI, MEHRDAD, SAGHARI, M., NOURANI, M.H., FARD ESFAHANI, A., FALAHI SICHANI, B., & BEYKI, D.. (2005). EVALUATION OF DIOAGNOSTIC ROLE OF 99MTC-TETROFOSMIN SCINTIGRAPHY IN COLD THYROID NODULES. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 13(24), 25-30. SID. https://sid.ir/paper/34225/en

Vancouver: Copy

EFTEKHARI MEHRDAD, SAGHARI M., NOURANI M.H., FARD ESFAHANI A., FALAHI SICHANI B., BEYKI D.. EVALUATION OF DIOAGNOSTIC ROLE OF 99MTC-TETROFOSMIN SCINTIGRAPHY IN COLD THYROID NODULES. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2005;13(24):25-30. Available from: https://sid.ir/paper/34225/en

IEEE: Copy

MEHRDAD EFTEKHARI, M. SAGHARI, M.H. NOURANI, A. FARD ESFAHANI, B. FALAHI SICHANI, and D. BEYKI, “EVALUATION OF DIOAGNOSTIC ROLE OF 99MTC-TETROFOSMIN SCINTIGRAPHY IN COLD THYROID NODULES,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 13, no. 24, pp. 25–30, 2005, [Online]. Available: https://sid.ir/paper/34225/en

Related Journal Papers