HEALTH-PROMOTING PROPERTIES OF WHEY PROTEIN IN HEMODIALYSIS PATIENTS

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SOHRABI ZAHRA; EFTEKHARI MOHAMMAD HASSAN; MAZLOOMI SEYED MOHAMMAD; AKBARZADE MARZIEH

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Journal Paper

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Journal: Nutrition and food in health and disease Year:2014 | Volume:1 | Issue:SUPPL. (1) Page(s): 247-247

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Title

HEALTH-PROMOTING PROPERTIES OF WHEY PROTEIN IN HEMODIALYSIS PATIENTS

Author(s)

SOHRABI ZAHRA | EFTEKHARI MOHAMMAD HASSAN | MAZLOOMI SEYED MOHAMMAD | AKBARZADE MARZIEH

Keywords

FAS GENE

WHEY PROTEIN

ESRD

CATALASE

Abstract

Hemodialysis patients encounter a lot of complications which roots from their disease condition and their therapeutic modalities. High oxidative stress, inflammation and other abnormalities are prevalent in this disease. Concerning the malnutrition problem in these patients, more attention was paid to protein sources with health-promoting properties which can improve their complications. One of the proteins discussed in this regard is WHEY PROTEIN. WHEY PROTEIN (WP) consists a heterogeneousgroup of proteins (i.e., b-lactoglobulin, alactalbumin, serum albumin, and immunoglobulins). This protein bears antioxidant activity as a result of cysteine abundance or the presence of glutamylcysteine groups.In addition it reducesthe FAS GENE expression and DNA segmentation in the apopototic pathways. This way, it can protect against hydrogen peroxide and inhibits the production of 8-hydroxy guanosine. This protein also regulates CATALASE and superoxide dismutase activities which are from the potent known antioxidative enzymes.Hence, this protein can be used as a therapeutic agent for oxidative stress-associated diseases such as ESRD (especially those on hemodialysis). Another characteristic of WHEY PROTEIN is its hypotensive effect due to its impacts on vascular function (NO-dependent and -independent vascular responses). On the other hand, this protein can affect insulin secretion through its effects on elevating serum amino acid levels, and GLP-1 and insulin-secreting peptide, while at the same time provokes glucose uptake by muscles through PK-C and PI3-K pathways. Additionally, WP possesses anti-inflammatory properties as well.So, regarding the health promoting effects of WHEY PROTEIN and complicated conditions of hemodialysis patients with high oxidative stress, inflammation, blood pressure and other metabolic abnormalities, this protein can be a good preventive and therapeutic supplement for use in this disease condition.

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APA: Copy

SOHRABI, ZAHRA, EFTEKHARI, MOHAMMAD HASSAN, MAZLOOMI, SEYED MOHAMMAD, & AKBARZADE, MARZIEH. (2014). HEALTH-PROMOTING PROPERTIES OF WHEY PROTEIN IN HEMODIALYSIS PATIENTS. NUTRITION AND FOOD SCIENCES RESEARCH, 1(SUPPL. (1)), 247-247. SID. https://sid.ir/paper/342701/en

Vancouver: Copy

SOHRABI ZAHRA, EFTEKHARI MOHAMMAD HASSAN, MAZLOOMI SEYED MOHAMMAD, AKBARZADE MARZIEH. HEALTH-PROMOTING PROPERTIES OF WHEY PROTEIN IN HEMODIALYSIS PATIENTS. NUTRITION AND FOOD SCIENCES RESEARCH[Internet]. 2014;1(SUPPL. (1)):247-247. Available from: https://sid.ir/paper/342701/en

IEEE: Copy

ZAHRA SOHRABI, MOHAMMAD HASSAN EFTEKHARI, SEYED MOHAMMAD MAZLOOMI, and MARZIEH AKBARZADE, “HEALTH-PROMOTING PROPERTIES OF WHEY PROTEIN IN HEMODIALYSIS PATIENTS,” NUTRITION AND FOOD SCIENCES RESEARCH, vol. 1, no. SUPPL. (1), pp. 247–247, 2014, [Online]. Available: https://sid.ir/paper/342701/en

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