COMBINATION OF EZETIMIBE AND GARLIC REDUCES SERUM LIPIDS AND INTESTINAL NIEMANN-PICK C1-LIKE 1 EXPRESSION MORE EFFECTIVELY IN HYPERCHOLESTEROLEMIC MICE

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MOHAMMADI ABBAS; Vafaei Seyyed Alireza; Moradi Mohammad Nabi; AHMADI MEHRDAD; POURJAFAR MONA; ABBASI OSHAGHI EBRAHIM

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Journal: Avicenna Journal of Medical Biochemistry Year:2015 | Volume:3 | Issue:1 Page(s): 0-0

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Title

COMBINATION OF EZETIMIBE AND GARLIC REDUCES SERUM LIPIDS AND INTESTINAL NIEMANN-PICK C1-LIKE 1 EXPRESSION MORE EFFECTIVELY IN HYPERCHOLESTEROLEMIC MICE

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Keywords

CHOLESTEROL

GARLIC

EZETIMIBE

HERBAL MEDICINE

HYPERCHOLESTEROLEMIA

Abstract

Background: Combination therapy plays an important role in the management of cardiovascular disease (CVD).Objectives: The aim of this experiment was to study the influence of GARLIC combined with EZETIMIBE on lipid profile as well as intestinal Niemann-Pick C1-like 1 (NPC1L1) expression in normal and hyperCHOLESTEROLemic mice.Materials and Methods: A total of 40 mice were randomly divided into five groups: Group 1: hyperCHOLESTEROLemic group (received 2% w/w CHOLESTEROL+0.5% w/w cholic acid in their diet), Group 2: GARLIC group (hyperCHOLESTEROLemic diet+4% w/w GARLIC extract), Group 3: EZETIMIBE group (hyperCHOLESTEROLemic diet+0.005% w/w EZETIMIBE), Group 4: combination group (hyperCHOLESTEROLemic diet+0.005% w/w EZETIMIBE+4% w/w GARLIC) and Group 5: control (chow only).Results: Serum low-density lipoprotein-CHOLESTEROL (LDL-C) and total CHOLESTEROL (TC) levels were significantly decreased in EZETIMIBE, GARLIC (both P<0.05), and combination groups (P<0.001). Also, triglycerides and very low-density lipoprotein-CHOLESTEROL (VLDL-C) were significantly lower in GARLIC and combination groups (P<0.05). Liver enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), were also significantly decreased in GARLIC, EZETIMIBE (both P<0.05) and combination groups (P<0.001) in comparison with hyperCHOLESTEROLemic animals. Analysis of semi quantitative RT-PCR results showed that the levels of NPC1L1 was also significantly less (P<0.01) in the GARLIC, EZETIMIBE, and combination groups (P<0.001) compared with the controls. Based on the results, the combination of GARLIC and EZETIMIBE can lower serum lipids and liver enzymes more effectively in hyperCHOLESTEROLemic mice.Conclusions: This experiment revealed that a possible mechanism for the beneficial effects of GARLIC and EZETIMIBE combination in lowering plasma LDL-C and TC is inhibition of intestinal CHOLESTEROL absorption. More research might be necessary to determine the efficacy and the exact mechanism of this co-administration.

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APA: Copy

MOHAMMADI, ABBAS, Vafaei, Seyyed Alireza, Moradi, Mohammad Nabi, AHMADI, MEHRDAD, POURJAFAR, MONA, & ABBASI OSHAGHI, EBRAHIM. (2015). COMBINATION OF EZETIMIBE AND GARLIC REDUCES SERUM LIPIDS AND INTESTINAL NIEMANN-PICK C1-LIKE 1 EXPRESSION MORE EFFECTIVELY IN HYPERCHOLESTEROLEMIC MICE. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, 3(1), 0-0. SID. https://sid.ir/paper/343020/en

Vancouver: Copy

MOHAMMADI ABBAS, Vafaei Seyyed Alireza, Moradi Mohammad Nabi, AHMADI MEHRDAD, POURJAFAR MONA, ABBASI OSHAGHI EBRAHIM. COMBINATION OF EZETIMIBE AND GARLIC REDUCES SERUM LIPIDS AND INTESTINAL NIEMANN-PICK C1-LIKE 1 EXPRESSION MORE EFFECTIVELY IN HYPERCHOLESTEROLEMIC MICE. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY[Internet]. 2015;3(1):0-0. Available from: https://sid.ir/paper/343020/en

IEEE: Copy

ABBAS MOHAMMADI, Seyyed Alireza Vafaei, Mohammad Nabi Moradi, MEHRDAD AHMADI, MONA POURJAFAR, and EBRAHIM ABBASI OSHAGHI, “COMBINATION OF EZETIMIBE AND GARLIC REDUCES SERUM LIPIDS AND INTESTINAL NIEMANN-PICK C1-LIKE 1 EXPRESSION MORE EFFECTIVELY IN HYPERCHOLESTEROLEMIC MICE,” AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, vol. 3, no. 1, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/343020/en

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