THE ASSOCIATION BETWEEN MATRIX METALLOPROTEINASE-7 A-181G POLYMORPHISM AND THE RISK OF RELAPSING REMITTING MULTIPLE SCLEROSIS IN IRANIAN KURDISH PATIENTS FROM KERMANSHAH

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MOHAMMADI FATEMEH; RAHIMI ZIBA; RAHIMI ZOHREH

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Journal: Avicenna Journal of Medical Biochemistry Year:2015 | Volume:3 | Issue:1 Page(s): 0-0

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Title

THE ASSOCIATION BETWEEN MATRIX METALLOPROTEINASE-7 A-181G POLYMORPHISM AND THE RISK OF RELAPSING REMITTING MULTIPLE SCLEROSIS IN IRANIAN KURDISH PATIENTS FROM KERMANSHAH

Author(s)

MOHAMMADI FATEMEH | RAHIMI ZIBA | RAHIMI ZOHREH | Issue Writer Certificate

Keywords

MATRIX METALLOPROTEINASE 7

POLYMORPHISM

GENETIC

MULTIPLE SCLEROSIS RELAPSING-REMITTING

Abstract

Background: Multiple sclerosis (MS) is a common chronic GENETIC disease of the central nervous system. The relapsing-remitting-MS (RR-MS) is the most common form of this disease. Matrix metalloproteinase-7 (MMP-7) is an important member of the MMP family, which degrades many extracellular matrix components. The common POLYMORPHISM of MMP-7 A-181G is associated with some diseases.Objectives: The aim of the present study was to determine the influence of this POLYMORPHISM on the risk of RR-MS.Materials and Methods: Eighty RR-MS patients and 80 healthy individuals as controls from the Kermanshah province were studied for MMP-7 A-181G POLYMORPHISM by using the PCR-RFLP method. Data were analyzed using the SPSS statistical software package version 16.0.Results: In RR-MS patients the frequency of MMP-7 GG genotype was significantly (P=0.028) higher compared to that of the controls. The presence of GG genotype increased the risk of RR-MS by 1.69 times [OR=1.69 and 95% CI=1.05- 2.72, P=0.03]. The frequency of MMP-7 G allele in RR-MS patients was significantly higher (51.2%, P=0.043) than that of the controls (40%). The presence of this allele increased the risk of RR-MS by 1.58 folds (P=0.044).Conclusions: Our findings indicate that the presence of G allele of MMP-7 A-181G POLYMORPHISM might increase the risk of RR-MS in our population.

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APA: Copy

MOHAMMADI, FATEMEH, RAHIMI, ZIBA, & RAHIMI, ZOHREH. (2015). THE ASSOCIATION BETWEEN MATRIX METALLOPROTEINASE-7 A-181G POLYMORPHISM AND THE RISK OF RELAPSING REMITTING MULTIPLE SCLEROSIS IN IRANIAN KURDISH PATIENTS FROM KERMANSHAH. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, 3(1), 0-0. SID. https://sid.ir/paper/343022/en

Vancouver: Copy

MOHAMMADI FATEMEH, RAHIMI ZIBA, RAHIMI ZOHREH. THE ASSOCIATION BETWEEN MATRIX METALLOPROTEINASE-7 A-181G POLYMORPHISM AND THE RISK OF RELAPSING REMITTING MULTIPLE SCLEROSIS IN IRANIAN KURDISH PATIENTS FROM KERMANSHAH. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY[Internet]. 2015;3(1):0-0. Available from: https://sid.ir/paper/343022/en

IEEE: Copy

FATEMEH MOHAMMADI, ZIBA RAHIMI, and ZOHREH RAHIMI, “THE ASSOCIATION BETWEEN MATRIX METALLOPROTEINASE-7 A-181G POLYMORPHISM AND THE RISK OF RELAPSING REMITTING MULTIPLE SCLEROSIS IN IRANIAN KURDISH PATIENTS FROM KERMANSHAH,” AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, vol. 3, no. 1, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/343022/en

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