The Induction of Apoptosis by Resveratrol Through Regulatory Effect of miR-21 on the Gene Expression of Bcl2 and Bax in HCT-116 Cells

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SHABAB NOOSHIN; AFSHAR SAEID; SAIDIJAM MASSOUD

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Journal: Avicenna Journal of Medical Biochemistry Year:2019 | Volume:7 | Issue:1 Page(s): 21-27

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Title

The Induction of Apoptosis by Resveratrol Through Regulatory Effect of miR-21 on the Gene Expression of Bcl2 and Bax in HCT-116 Cells

Author(s)

SHABAB NOOSHIN | AFSHAR SAEID | SAIDIJAM MASSOUD | Issue Writer Certificate

Keywords

Resveratrol

miR-21

Bcl2

Bax

Apoptosis

Colorectal neoplasm

Abstract

Background: Resveratrol (RezV) which is found in several plants including grapes and types of berries has a vital role in inducing Apoptosis and suppressing cell proliferation. Although the role of Bcl-2 in the Apoptosis has been known in several pathways, the role and mechanism of miR-21 in the regulation of Apoptosis in colorectal cancer (CRC) cells are unclear. Objectives: The main aim of this study was to evaluate the effects of RezV on the expression level of miR-21, Bax, and Bcl2 in colorectal tumor cells. Methods: In this study, the effect of RezV on the viability of CRC cells was evaluated by MTT assay. Then, the expression level of miR-21 was evaluated by real-time polymerase chain reaction (PCR) method. For evaluating HCT-116 cells Apoptosis, the expression level of Bax and Bcl2 that are involved in the Apoptosis pathway was investigated by the same method. Results: RezV inhibits the viability of HCT-116 cells. miR-21 gene expression was decreased after 24 hours of treatment with RezV. The reduction of miR-21 expression leads to the reduction of the Bcl2 gene expression level. Moreover, increasing the Bax/Bcl2 ratio enhances HCT-116 cells Apoptosis. Conclusion: In summary, RezV might be used as a co-treatment agent for CRC. On the other hand, conducting the in vivo study to evaluate the effects of RezV was critical.

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APA: Copy

SHABAB, NOOSHIN, AFSHAR, SAEID, & SAIDIJAM, MASSOUD. (2019). The Induction of Apoptosis by Resveratrol Through Regulatory Effect of miR-21 on the Gene Expression of Bcl2 and Bax in HCT-116 Cells. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, 7(1), 21-27. SID. https://sid.ir/paper/343072/en

Vancouver: Copy

SHABAB NOOSHIN, AFSHAR SAEID, SAIDIJAM MASSOUD. The Induction of Apoptosis by Resveratrol Through Regulatory Effect of miR-21 on the Gene Expression of Bcl2 and Bax in HCT-116 Cells. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY[Internet]. 2019;7(1):21-27. Available from: https://sid.ir/paper/343072/en

IEEE: Copy

NOOSHIN SHABAB, SAEID AFSHAR, and MASSOUD SAIDIJAM, “The Induction of Apoptosis by Resveratrol Through Regulatory Effect of miR-21 on the Gene Expression of Bcl2 and Bax in HCT-116 Cells,” AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, vol. 7, no. 1, pp. 21–27, 2019, [Online]. Available: https://sid.ir/paper/343072/en

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