Synthesis and In Vitro Antibacterial Evaluation of Schiff Bases Derived FROM 2-Chloro-3-Quinolinecarboxaldehyde

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Beyzaei Hamid; Hosseini Moghadam Hadis; BAGHERZADE GHODSIEH; Aryan Reza; Moghaddam Manesh Mohammad reza

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Journal: Avicenna Journal of Medical Biochemistry Year:2019 | Volume:7 | Issue:1 Page(s): 9-15

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Title

Synthesis and In Vitro Antibacterial Evaluation of Schiff Bases Derived FROM 2-Chloro-3-Quinolinecarboxaldehyde

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Keywords

Antibacterial effect

Broth microdilution

Disc diffusion

In vitro study

Quinoline Schiff base

Time-kill

Abstract

Background: Design, identification, and synthesis of new antimicrobial agents along with preventive proceedings are essential to confront antibiotic-resistant pathogenic bacteria. Heterocyclic Schiff bases are biologically important compounds whose antimicrobial potentials have been proven to bacterial and fungal pathogens. Objectives: In this study, some Quinoline Schiff bases were synthesized from condensation of 2-chloro-3-quinolinecarboxaldehyde and aniline derivatives. Their inhibitory activities were evaluated against 6 gram-positive and 2 gram-negative bacterial pathogens. Methods: Disc diffusion, Broth microdilution, and Time-kill tests were applied according to the CLSI guidelines to determine IZD, MIC, and MBC values. Results: 2-Chloro-3-quinolinecarboxaldehyde Schiff bases could inhibit the growth of bacteria with IZDs of 7. 5-19. 8 mm, MICs of 256-2048 μ g mL-1, and MBCs of 512 to ≥ 2048 μ g mL-1. Conclusion: Moderate Antibacterial effects were observed with heterocyclic Schiff bases. Complexation and structural changes can improve their antimicrobial properties.

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APA: Copy

Beyzaei, Hamid, Hosseini Moghadam, Hadis, BAGHERZADE, GHODSIEH, Aryan, Reza, & Moghaddam Manesh, Mohammad reza. (2019). Synthesis and In Vitro Antibacterial Evaluation of Schiff Bases Derived FROM 2-Chloro-3-Quinolinecarboxaldehyde. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, 7(1), 9-15. SID. https://sid.ir/paper/343075/en

Vancouver: Copy

Beyzaei Hamid, Hosseini Moghadam Hadis, BAGHERZADE GHODSIEH, Aryan Reza, Moghaddam Manesh Mohammad reza. Synthesis and In Vitro Antibacterial Evaluation of Schiff Bases Derived FROM 2-Chloro-3-Quinolinecarboxaldehyde. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY[Internet]. 2019;7(1):9-15. Available from: https://sid.ir/paper/343075/en

IEEE: Copy

Hamid Beyzaei, Hadis Hosseini Moghadam, GHODSIEH BAGHERZADE, Reza Aryan, and Mohammad reza Moghaddam Manesh, “Synthesis and In Vitro Antibacterial Evaluation of Schiff Bases Derived FROM 2-Chloro-3-Quinolinecarboxaldehyde,” AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, vol. 7, no. 1, pp. 9–15, 2019, [Online]. Available: https://sid.ir/paper/343075/en

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