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Information Journal Paper

Title

IN SILICO ANALYSIS AND MOLECULAR MODELING OF RNA POLYMERASE, SIGMA S (RPOS) PROTEIN IN PSEUDOMONAS AERUGINOSA PAO1

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Abstract

 Background: Sigma factors are proteins that regulate transcription in bacteria. Sigma factors can be activated in response to different environmental conditions. The RPOS (RNA polymerase, sigma S) gene encodes sigma-38 (σ38, or RPOS), a 37.8 kDa protein inPseudomonas aeruginosa (P. aeruginosa) strains. RPOS is a central regulator of the general stress response and operates in both retroactive and proactive manners; not only does it allow the cell to survive environmental challenges; it also prepares the cell for subsequent stresses (cross-protection).Methods: The significance of RPOS for stress resistance and protein expression in stationary-phase P. aeruginosa cells was assessed. The goal of the current study was to characterize RPOS ofP. aeruginosa PAO1 using BIOINFORMATICS tools.Results: The results showed that RPOS is an unstable protein that belongs to the sigma-70 factor family. Secondary structure analysis predicted that random coil is the predominant structure followed by extended alpha helix. The three-dimensional (3D) structure was modeled using SWISS-MODEL Workspace.Conclusion: Determination of sequence, function, structure, and predicted epitopes of RPOS is important for modeling of inhibitors that will help in the design of new drugs to combat multi-drug-resistant (MDR) strains. Such information may aid in the development of new diagnostic tools, drugs, and vaccines for treatment in endemic regions.

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    APA: Copy

    SEDIGHI, MANSOUR, MOGHOOFEI, MOHSEN, KOUHSARI, EBRAHIM, POURNAJAF, ABAZAR, EMADI, BEHZAD, TOHIDFAR, MASOUD, & GHOLAMI, MEHRDAD. (2015). IN SILICO ANALYSIS AND MOLECULAR MODELING OF RNA POLYMERASE, SIGMA S (RPOS) PROTEIN IN PSEUDOMONAS AERUGINOSA PAO1. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 4(1), 0-0. SID. https://sid.ir/paper/343091/en

    Vancouver: Copy

    SEDIGHI MANSOUR, MOGHOOFEI MOHSEN, KOUHSARI EBRAHIM, POURNAJAF ABAZAR, EMADI BEHZAD, TOHIDFAR MASOUD, GHOLAMI MEHRDAD. IN SILICO ANALYSIS AND MOLECULAR MODELING OF RNA POLYMERASE, SIGMA S (RPOS) PROTEIN IN PSEUDOMONAS AERUGINOSA PAO1. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2015;4(1):0-0. Available from: https://sid.ir/paper/343091/en

    IEEE: Copy

    MANSOUR SEDIGHI, MOHSEN MOGHOOFEI, EBRAHIM KOUHSARI, ABAZAR POURNAJAF, BEHZAD EMADI, MASOUD TOHIDFAR, and MEHRDAD GHOLAMI, “IN SILICO ANALYSIS AND MOLECULAR MODELING OF RNA POLYMERASE, SIGMA S (RPOS) PROTEIN IN PSEUDOMONAS AERUGINOSA PAO1,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 4, no. 1, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/343091/en

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