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Title

IN SILICO ANALYSIS AND MODELING OF ACP-MIP–PILQ CHIMERIC ANTIGEN FROM NEISSERIA MENINGITIDIS SEROGROUP B

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Abstract

 Background: Neisseria meningitidis, a life-threatening human pathogen with the potential to cause large epidemics, can be isolated from the nasopharynx of 5–15% of adults. The aim of the current study was to evaluate biophysical and biochemical properties and immunological aspects of chimeric acyl-carrier protein-macrophage infectivity potentiator protein-type IV pilus biogenesis protein antigen (ACP-MIP-PilQ) fromN. meningitidis SEROGROUP B strain.Methods: Biochemical properties and multiple alignments were predicted by appropriate web servers. Secondary molecular structures were predicted based on Chou and Fasman, Garnier-Osguthorpe-Robson, and Neural Network methods. Tertiary modeling elucidated conformational properties of the CHIMERIC PROTEIN.Proteasome cleavage and transporter associated with antigen processing (TAP) binding sites, and T- and B-cell antigenic epitopes, were predicted using bioinformatic web servers.Results: Based on our IN SILICO and immunoinformatics analyses, the ACP-MIP-PilQ protein (AMP) can induce high-level cross-strain bactericidal activity. In addition, several immune proteasomal cleavage sites were detected.The 22 epitopes associated with MHC class I and class II (DR) alleles were confirmed in the AMP. Thirty linear Bcell epitopes as antigenic regions were predicted from the full-length protein.Conclusion: All predicted properties of the AMP indicate it could be a good candidate for further immunological in vitroand in vivo studies.

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    APA: Copy

    GHOLAMI, MEHRDAD, SALIMI CHIRANI, ALIREZA, MOSHIRI, MONA, SEDIGHI, MANSOUR, POURNAJAF, ABAZAR, TOHIDFAR, MASOUD, & IRAJIAN, GHOLAMREZA. (2015). IN SILICO ANALYSIS AND MODELING OF ACP-MIP–PILQ CHIMERIC ANTIGEN FROM NEISSERIA MENINGITIDIS SEROGROUP B. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 4(1), 0-0. SID. https://sid.ir/paper/343093/en

    Vancouver: Copy

    GHOLAMI MEHRDAD, SALIMI CHIRANI ALIREZA, MOSHIRI MONA, SEDIGHI MANSOUR, POURNAJAF ABAZAR, TOHIDFAR MASOUD, IRAJIAN GHOLAMREZA. IN SILICO ANALYSIS AND MODELING OF ACP-MIP–PILQ CHIMERIC ANTIGEN FROM NEISSERIA MENINGITIDIS SEROGROUP B. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2015;4(1):0-0. Available from: https://sid.ir/paper/343093/en

    IEEE: Copy

    MEHRDAD GHOLAMI, ALIREZA SALIMI CHIRANI, MONA MOSHIRI, MANSOUR SEDIGHI, ABAZAR POURNAJAF, MASOUD TOHIDFAR, and GHOLAMREZA IRAJIAN, “IN SILICO ANALYSIS AND MODELING OF ACP-MIP–PILQ CHIMERIC ANTIGEN FROM NEISSERIA MENINGITIDIS SEROGROUP B,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 4, no. 1, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/343093/en

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