TRANSCRIPTIONAL ANALYSIS OF VEGF-D AND TGFβ GENES IN MCF7 CELLS EXPOSED TO SAPONIN ISOLATED FROM HOLOTHURIA LEUCOSPILOTA (SEA CUCUMBER)

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SOLTANI MOZHGAN; PARIVAR KAZEM; BAHARARA JAVAD; KERACHIAN MOHAMMAD AMIN; ASILI JAVAD

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Journal: REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY Year:2015 | Volume:4 | Issue:1 Page(s): 0-0

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Title

TRANSCRIPTIONAL ANALYSIS OF VEGF-D AND TGFβ GENES IN MCF7 CELLS EXPOSED TO SAPONIN ISOLATED FROM HOLOTHURIA LEUCOSPILOTA (SEA CUCUMBER)

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Keywords

SEA CUCUMBER

SAPONIN

ANGIOGENESIS

ANTICANCER

Abstract

Background: Marine natural products contain a wide range of bioactive compounds with therapeutic properties that have revealed crucial properties in the treatment of some diseases. Some of these compounds have recently received considerable attention for drug discovery. In this study we examined the anti-angiogenic effect of SAPONIN isolated from Holothuria leucospilota (SEA CUCUMBER) through evaluation of vascular endothelial growth factor D (VEGF-D) and transforming growth factor-b (TGFb) expression in a breast cancer cell line.Methods: To investigate the effect of SCS on VEGF-D and TGF-b expression in breast cancer cells, the cells were treated with various concentrations of sample. After 48 h the viability of the cells was evaluated by trypan blue staining, and VEGF-D and TGFb mRNA expression was were evaluated by real time-PCR.Results: Our results revealed that SCS can suppress cell viability and VEGF-D and TGFb mRNA expression in breast cancer cells. SEA CUCUMBER SAPONIN at a concentration of 12 mg/ml inhibited VEGF-D and TGFb expression more than 90% compared with controls.Conclusion: Findings suggest that SCS could inhibit tumor growth via inhibition of ANGIOGENESIS.

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APA: Copy

SOLTANI, MOZHGAN, PARIVAR, KAZEM, BAHARARA, JAVAD, KERACHIAN, MOHAMMAD AMIN, & ASILI, JAVAD. (2015). TRANSCRIPTIONAL ANALYSIS OF VEGF-D AND TGFβ GENES IN MCF7 CELLS EXPOSED TO SAPONIN ISOLATED FROM HOLOTHURIA LEUCOSPILOTA (SEA CUCUMBER). REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 4(1), 0-0. SID. https://sid.ir/paper/343095/en

Vancouver: Copy

SOLTANI MOZHGAN, PARIVAR KAZEM, BAHARARA JAVAD, KERACHIAN MOHAMMAD AMIN, ASILI JAVAD. TRANSCRIPTIONAL ANALYSIS OF VEGF-D AND TGFβ GENES IN MCF7 CELLS EXPOSED TO SAPONIN ISOLATED FROM HOLOTHURIA LEUCOSPILOTA (SEA CUCUMBER). REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2015;4(1):0-0. Available from: https://sid.ir/paper/343095/en

IEEE: Copy

MOZHGAN SOLTANI, KAZEM PARIVAR, JAVAD BAHARARA, MOHAMMAD AMIN KERACHIAN, and JAVAD ASILI, “TRANSCRIPTIONAL ANALYSIS OF VEGF-D AND TGFβ GENES IN MCF7 CELLS EXPOSED TO SAPONIN ISOLATED FROM HOLOTHURIA LEUCOSPILOTA (SEA CUCUMBER),” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 4, no. 1, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/343095/en

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