PROTECTIVE EFFECTS OF WITHANIA SOMNIFERA ROOT ON INFLAMMATORY MARKERS AND INSULIN RESISTANCE IN FRUCTOSE-FED RATS

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SAMADI NOSHAHR ZAHRA; SHAHRAKI MOHAMMAD REZA; AHMADVAND HASSAN; NOURABADI DAVOOD; NAKHAEI ALIREZA

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Journal: REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY Year:2015 | Volume:3 | Issue:2 Page(s): 0-0

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Title

PROTECTIVE EFFECTS OF WITHANIA SOMNIFERA ROOT ON INFLAMMATORY MARKERS AND INSULIN RESISTANCE IN FRUCTOSE-FED RATS

Author(s)

Keywords

WITHANIA SOMNIFERA

INSULIN RESISTANCE

IL-6

TNF-α

Abstract

Background: We investigated the effects of WITHANIA SOMNIFERA root (WS) on INSULIN RESISTANCE, tumor necrosis factor a (TNF-a), and interleukin-6 (IL-6) in fructose-fed rats.Methods: Forty-eight Wistar-Albino male rats were randomly divided into four groups (n=12); Group I as control, Group II as sham-treated with WS by 62.5mg/g per diet, Group III fructose-fed rats received 10%W/V fructose, and Group IV fructose- and WS-fed rats. After eight weeks blood samples were collected to measure glucose, insulin, IL-6, and TNF-a levels in sera.Results: Blood glucose, insulin, homeostasis model assessment for INSULIN RESISTANCE (HOMA-R), IL-6, and TNF-a levels were all significantly greater in the fructose-fed rats than in the controls. Treatment with WS significantly (P<0.05) inhibited the fructose-induced increases in glucose, insulin, HOMA-R, IL-6, and TNF- a.Conclusion: Our data suggest that WS normalizes hyperglycemia in fructose-fed rats by reducing inflammatory markers and improving insulin sensitivity.

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APA: Copy

SAMADI NOSHAHR, ZAHRA, SHAHRAKI, MOHAMMAD REZA, AHMADVAND, HASSAN, NOURABADI, DAVOOD, & NAKHAEI, ALIREZA. (2015). PROTECTIVE EFFECTS OF WITHANIA SOMNIFERA ROOT ON INFLAMMATORY MARKERS AND INSULIN RESISTANCE IN FRUCTOSE-FED RATS. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 3(2), 0-0. SID. https://sid.ir/paper/343106/en

Vancouver: Copy

SAMADI NOSHAHR ZAHRA, SHAHRAKI MOHAMMAD REZA, AHMADVAND HASSAN, NOURABADI DAVOOD, NAKHAEI ALIREZA. PROTECTIVE EFFECTS OF WITHANIA SOMNIFERA ROOT ON INFLAMMATORY MARKERS AND INSULIN RESISTANCE IN FRUCTOSE-FED RATS. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2015;3(2):0-0. Available from: https://sid.ir/paper/343106/en

IEEE: Copy

ZAHRA SAMADI NOSHAHR, MOHAMMAD REZA SHAHRAKI, HASSAN AHMADVAND, DAVOOD NOURABADI, and ALIREZA NAKHAEI, “PROTECTIVE EFFECTS OF WITHANIA SOMNIFERA ROOT ON INFLAMMATORY MARKERS AND INSULIN RESISTANCE IN FRUCTOSE-FED RATS,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 3, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/343106/en

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