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Information Journal Paper

Title

ASSOCIATION BETWEEN METALLO-β-LACTAMASES AND INTEGRONS WITH MULTI- DRUG RESISTANCE IN PSEUDOMONAS AERUGINOSA ISOLATES

Pages

  46-51

Abstract

 Pseudomonas aeruginosa is among the most important pathogens in the nosocomial infections. A genetic mobile element, the INTEGRON, is one of the major agents involved in dissemination of multi-drug resistance among gram negative bacteria. During a descriptive study from October 2009 to August 2010, some 130 P. aeruginosa clinical isolates were collected from different wards of three hospitals in Tehran. The Minimal inhibitory concentration (MIC) of 4 antibiotics conventionally used in clinical settings against the isolates was determined by E-test method. Also, the existence of INTEGRON classes and metallo-b-lactamases (blaVIM-1, blaIMP-1, and blaVIM-2) were investigated by PCR assay. Out of 130 isolates, 74 (56.9%) carried class 1 INTEGRON. None of the isolates harbored INTEGRONs class 2 and 3. Also, the blaVIM-1 gene was detected in 10 (13.3%) high level ceftazidime and imipenem- resistant isolates that carried class 1 INTEGRONs. The blaIMP-1 and blaVIM-2 genes were not detected in any isolates. In the present study, the ANTIBIOTIC RESISTANCE rates in class 1 INTEGRON-positive isolates of P. aeruginosa were significantly higher than those lacking this INTEGRON, e.g., 82.6% resistance versus 17.3% sensitivity to ceftazidime. Also, 13.3% of ceftazidime and imipenem resistant isolates was metallo-b-lactamase producer. This indicates that all metallo-b-lactamase genes are correlated with class 1 INTEGRONs. These results imply that the blaVIM-1 gene has been presumably dispersed into P.aeruginosa isolates with the help of class 1 INTEGRON element.

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    • Cite

    APA: Copy

    AZAMI, SOMAYEH, ABDI ALI, AHYA, & ASGARANI, EZZAT. (2013). ASSOCIATION BETWEEN METALLO-β-LACTAMASES AND INTEGRONS WITH MULTI- DRUG RESISTANCE IN PSEUDOMONAS AERUGINOSA ISOLATES. JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES, 1(1), 46-51. SID. https://sid.ir/paper/343157/en

    Vancouver: Copy

    AZAMI SOMAYEH, ABDI ALI AHYA, ASGARANI EZZAT. ASSOCIATION BETWEEN METALLO-β-LACTAMASES AND INTEGRONS WITH MULTI- DRUG RESISTANCE IN PSEUDOMONAS AERUGINOSA ISOLATES. JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES[Internet]. 2013;1(1):46-51. Available from: https://sid.ir/paper/343157/en

    IEEE: Copy

    SOMAYEH AZAMI, AHYA ABDI ALI, and EZZAT ASGARANI, “ASSOCIATION BETWEEN METALLO-β-LACTAMASES AND INTEGRONS WITH MULTI- DRUG RESISTANCE IN PSEUDOMONAS AERUGINOSA ISOLATES,” JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES, vol. 1, no. 1, pp. 46–51, 2013, [Online]. Available: https://sid.ir/paper/343157/en

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