Letter to the Editor: Hardy Weinberg Equilibrium Testing and Interpretation Focus on Infection

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EYBPOOSH SANA

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Paper Information

Journal: JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES Year:2018 | Volume:6 | Issue:1 Page(s): 35-36

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Title

Letter to the Editor: Hardy Weinberg Equilibrium Testing and Interpretation Focus on Infection

Author(s)

EYBPOOSH SANA | Issue Writer Certificate

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Abstract

To the editor: Recent advances in genetic association (GA) studies have reported novel associations betweencommon genetic markers and human susceptibility to many major infectious diseases. In parallel, an increasing number of rare genetic variants have been identified that areassociated with susceptibility to infection. Together, theseachievements have highlighted the genetic architecture ofinfectious disease susceptibility and illuminated immuneand cellular pathways that are associated with the infectionprocess. However, for a genetic association study to yieldvalid results, particular considerations on study design andconduct are required to be taken. Application of GA studiesin the field of infectious diseases is at its early stage, callingthe need for further elaborations on design considerationsof these studies. Perhaps one of the most commonly referred approach in GA studies is to test for “ HardyWeinberg equilibrium” (HWE, described below) principle. However, this principle is frequently disregarded or missinterpreted in GA studies of infectious diseases. So, in thispiece, I would further elaborate on this concept, itsapplications, and its testing and interpretation.

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APA: Copy

. (2018). Letter to the Editor: Hardy Weinberg Equilibrium Testing and Interpretation Focus on Infection. JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES, 6(1), 35-36. SID. https://sid.ir/paper/343173/en

Vancouver: Copy

. Letter to the Editor: Hardy Weinberg Equilibrium Testing and Interpretation Focus on Infection. JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES[Internet]. 2018;6(1):35-36. Available from: https://sid.ir/paper/343173/en

IEEE: Copy

, “Letter to the Editor: Hardy Weinberg Equilibrium Testing and Interpretation Focus on Infection,” JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES, vol. 6, no. 1, pp. 35–36, 2018, [Online]. Available: https://sid.ir/paper/343173/en

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