Leishmanicidal and Cytotoxic Activity of Algerian Medicinal Plants on Leishmania major and Leishmania infantum

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Eddaikra Naouel; Boudjelal Amel; Sbabdji Mohamed Amine; Eddaikra Atika; Boudrissa Abdelkrim; Mounir Bouhenna Mustapha; Chemat Smain; Harrat Zoubir

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Journal: JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES Year:2019 | Volume:7 | Issue:3 Page(s): 66-71

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Title

Leishmanicidal and Cytotoxic Activity of Algerian Medicinal Plants on Leishmania major and Leishmania infantum

Author(s)

Keywords

Leishmanicidal effect

Medicinal plant

Algeria

Leishmaniasis

Abstract

Introduction: Leishmaniasis is a severe disease that presents a real public health problem worldwide. Antileishmanial therapy remains expensive with intolerable side effects; therefore, it is essential to develop tolerable antileishmanial medications with a selective efficacy. Methods: In this study, the leishmanicidal activities of seven Algerian plant extracts, selected based on either ethnobotanical or chemotaxonomical data, were screened for their antileishmanial activity against promastigotes and amastigotes of cutaneous Leishmaniasis agent Leishmania major (MON 25), and visceral Leishmaniasis agent Leishmania infantum (MON 1). The cytotoxic activity against human monocytes THP1 was also determined. Results: In both species, amastigotes showed more sensitivity to the extracts than promastigotes. Erica arborea flower (IC50=43, 98 𝜇 g/mL), Marrubium vulgare leaves (IC50=45, 84 𝜇 g/mL) and Artemisia herba-alba Asso aerial parts (IC50=55, 21 𝜇 g/mL) had an almost similar inhibitory effect on L. major promastigote. Marrubium vulgare leaves (IC50=35, 63 𝜇 g/mL) was most effective against L. infantum promastigotes. Besides, these extracts exhibited low selectivity indices. The best results were obtained with M. vulgare on both L. major and L. infantum promastigotes (IC50s of 45, 84 μ g/ml and 35, 63 μ g/ml), and amastigotes (IC50s of 32, 15 μ g/ml and 18, 64 μ g/ml). The selectivity index was above two (2. 34 for L. major and 3. 01 for L. infantum), calculated based on the acceptable cytotoxic effect of M. vulgare on human macrophage cell line (CC50=107, 45 μ g/ml). Conclusion: Out of the seven methanol extracts tested against promastigotes of L. major and L. infantum, three showed promising activity with potent Leishmanicidal effect and acceptable selectivity indices on L. major and L. Infantum.

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References

Antimony susceptibility of Leishmania isolates collected over a 30-year period in Algeria

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APA: Copy

Eddaikra, Naouel, Boudjelal, Amel, Sbabdji, Mohamed Amine, Eddaikra, Atika, Boudrissa, Abdelkrim, Mounir Bouhenna, Mustapha, Chemat, Smain, & Harrat, Zoubir. (2019). Leishmanicidal and Cytotoxic Activity of Algerian Medicinal Plants on Leishmania major and Leishmania infantum. JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES, 7(3), 66-71. SID. https://sid.ir/paper/343219/en

Vancouver: Copy

Eddaikra Naouel, Boudjelal Amel, Sbabdji Mohamed Amine, Eddaikra Atika, Boudrissa Abdelkrim, Mounir Bouhenna Mustapha, Chemat Smain, Harrat Zoubir. Leishmanicidal and Cytotoxic Activity of Algerian Medicinal Plants on Leishmania major and Leishmania infantum. JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES[Internet]. 2019;7(3):66-71. Available from: https://sid.ir/paper/343219/en

IEEE: Copy

Naouel Eddaikra, Amel Boudjelal, Mohamed Amine Sbabdji, Atika Eddaikra, Abdelkrim Boudrissa, Mustapha Mounir Bouhenna, Smain Chemat, and Zoubir Harrat, “Leishmanicidal and Cytotoxic Activity of Algerian Medicinal Plants on Leishmania major and Leishmania infantum,” JOURNAL OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASES, vol. 7, no. 3, pp. 66–71, 2019, [Online]. Available: https://sid.ir/paper/343219/en

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