FRANKINCENSE IMPROVES MEMORY RETRIEVAL IN RATS TREATED WITH LIPOPOLYSACCHARIDE

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BEHESHTI SIAMAK; KARIMI BAHAREH

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Journal: JOURNAL OF HERBMED PHARMACOLOGY Year:2016 | Volume:5 | Issue:1 Page(s): 12-16

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Title

FRANKINCENSE IMPROVES MEMORY RETRIEVAL IN RATS TREATED WITH LIPOPOLYSACCHARIDE

Author(s)

BEHESHTI SIAMAK | KARIMI BAHAREH | Issue Writer Certificate

Keywords

LIPOPOLYSACCHARIDE

MEMORY

FRANKINCENSE

NEUROINFLAMMATION

Abstract

Introduction: FRANKINCENSE has been shown to possess anti-inflammatory activity. In this study the effect of pretreatment with the hydro-alcoholic extract of FRANKINCENSE on MEMORY retrieval was assessed in LIPOPOLYSACCHARIDE (LPS) treated rats.Methods: Forty-two adult male Wistar rats were distributed into 7 groups of 6 each. One group received LPS (1 mg/kg; i.p) pre-test. The control group received saline (1 ml/kg; i.p).2 groups of animals received FRANKINCENSE (50 mg/kg; P.O) or DMSO 5% (1 ml/kg; P.O) and 30 minutes later LPS (1 mg/kg; i.p). Two other groups of animals received FRANKINCENSE (50 mg/kg; P.O) or DMSO 5% (1 ml/kg; P.O) and 30 minutes later saline (1 ml/kg; i.p). Another group of rats received LPS (1 mg/kg; i.p) and 30 minutes later Ibuprofen (100 mg/kg; P.O). In all the experimental groups, MEMORY retrieval was assessed 4 hours following the last injection, using a passive avoidance task (PAT). Hippocampal TNF-α levels were measured by ELISA as an index of LPS-induced NEUROINFLAMMATION.Results: LPS impaired MEMORY retrieval by decreasing step-through latency (STL), significantly. LPS also increased levels of TNF-a in the hippocampus as compared to the control group. Administration of FRANKINCENSE (50 mg/kg; P.O) before LPS (1 mg/kg; i.p) improved MEMORY retrieval as compared to the control group. FRANKINCENSE reduced hippocampal TNF-a level in the LPS treated rats, significantly, compared to the control group.Conclusion: The results indicate that the hydro-alcoholic extract of FRANKINCENSE has the potential to improve MEMORY retrieval in LPS treated rats, possibly via an anti-neuroinflammatory activity.

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APA: Copy

BEHESHTI, SIAMAK, & KARIMI, BAHAREH. (2016). FRANKINCENSE IMPROVES MEMORY RETRIEVAL IN RATS TREATED WITH LIPOPOLYSACCHARIDE. JOURNAL OF HERBMED PHARMACOLOGY, 5(1), 12-16. SID. https://sid.ir/paper/343626/en

Vancouver: Copy

BEHESHTI SIAMAK, KARIMI BAHAREH. FRANKINCENSE IMPROVES MEMORY RETRIEVAL IN RATS TREATED WITH LIPOPOLYSACCHARIDE. JOURNAL OF HERBMED PHARMACOLOGY[Internet]. 2016;5(1):12-16. Available from: https://sid.ir/paper/343626/en

IEEE: Copy

SIAMAK BEHESHTI, and BAHAREH KARIMI, “FRANKINCENSE IMPROVES MEMORY RETRIEVAL IN RATS TREATED WITH LIPOPOLYSACCHARIDE,” JOURNAL OF HERBMED PHARMACOLOGY, vol. 5, no. 1, pp. 12–16, 2016, [Online]. Available: https://sid.ir/paper/343626/en

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