ANTICANCER ACTIVITY OF ETHANOLIC EXTRACT OF PROPOLIS ON AGS CELL LINE

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AMINI SARTESHNIZI NEMATALLAH; MOBINI DEHKORDI MOHSEN; KHOSRAVI FARSANI SOMAYEH; TEIMORI HOSSEIN

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Paper Information

Journal: JOURNAL OF HERBMED PHARMACOLOGY Year:2015 | Volume:4 | Issue:1 Page(s): 29-34

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Title

ANTICANCER ACTIVITY OF ETHANOLIC EXTRACT OF PROPOLIS ON AGS CELL LINE

Author(s)

AMINI SARTESHNIZI NEMATALLAH | MOBINI DEHKORDI MOHSEN | KHOSRAVI FARSANI SOMAYEH | TEIMORI HOSSEIN | Issue Writer Certificate

Keywords

PROPOLIS

AGS

MTT

VIABILITY

Abstract

Introduction: PROPOLIS is a natural product derived from various plant resins collected by honeybees, and has been used as a folk medicine for centuries. PROPOLIS has been reported to exhibit a broad spectrum of activities including antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, hepatoprotective, and anticancer properties. The aim of this study was to investigate the effect of ethanolic extract of PROPOLIS (EEP) obtained from Dinaran area (Iran) on AGS human gastric cancer cell line.Methods: The ethanolic extract of samples was obtained by ethanol 96% and pure extract was dissolved in dimethyl sulfoxide (DMSO) and used for experiments. The cytotoxic effects of various concentrations of EEP on AGS cells were investigated by MTT assay test after 24, 48, and 72 hours and compared with control cells.Results: The EEP inhibited the growth and proliferation of AGS human gastric cancer cell line. The ant iproliferative effects were revealed in a dose and time-dependent manner. The IC50 values were recorded as 60, 30, and 15 (mg/ml) in treatment times of 24, 48 and 72 hours, respectively.Conclusion: These findings indicated that the native EEP has strong ant iproliferative effects against cancerous AGS cells. Thus, PROPOLIS and related products may provide a novel approach to the chemoprevention and treatment of human gastric cancer.

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APA: Copy

AMINI SARTESHNIZI, NEMATALLAH, MOBINI DEHKORDI, MOHSEN, KHOSRAVI FARSANI, SOMAYEH, & TEIMORI, HOSSEIN. (2015). ANTICANCER ACTIVITY OF ETHANOLIC EXTRACT OF PROPOLIS ON AGS CELL LINE. JOURNAL OF HERBMED PHARMACOLOGY, 4(1), 29-34. SID. https://sid.ir/paper/343636/en

Vancouver: Copy

AMINI SARTESHNIZI NEMATALLAH, MOBINI DEHKORDI MOHSEN, KHOSRAVI FARSANI SOMAYEH, TEIMORI HOSSEIN. ANTICANCER ACTIVITY OF ETHANOLIC EXTRACT OF PROPOLIS ON AGS CELL LINE. JOURNAL OF HERBMED PHARMACOLOGY[Internet]. 2015;4(1):29-34. Available from: https://sid.ir/paper/343636/en

IEEE: Copy

NEMATALLAH AMINI SARTESHNIZI, MOHSEN MOBINI DEHKORDI, SOMAYEH KHOSRAVI FARSANI, and HOSSEIN TEIMORI, “ANTICANCER ACTIVITY OF ETHANOLIC EXTRACT OF PROPOLIS ON AGS CELL LINE,” JOURNAL OF HERBMED PHARMACOLOGY, vol. 4, no. 1, pp. 29–34, 2015, [Online]. Available: https://sid.ir/paper/343636/en

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