EFFECTS OF ZINGIBER OFFICINALE HYDRO-ALCOHOLIC EXTRACT ON HMG-COA REDUCTASE LEVEL IN THE TESTIS OF STREPTOZOTOCIN-INDUCED DIABETIC RATS

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MORADI PODEH BAHMAN; KHEIROLLAH ALIREZA; AHMMADPOUR FATEMEH; LAMUCHI DELI NASRIN; PAYAMI SEYEDE AREFE; MOHAMMADZADEH GHORBAN

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Journal: JOURNAL OF HERBMED PHARMACOLOGY Year:2018 | Volume:7 | Issue:2 Page(s): 94-99

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Title

EFFECTS OF ZINGIBER OFFICINALE HYDRO-ALCOHOLIC EXTRACT ON HMG-COA REDUCTASE LEVEL IN THE TESTIS OF STREPTOZOTOCIN-INDUCED DIABETIC RATS

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Keywords

STREPTOZOTOCIN-INDUCED DIABETES

HMG-COA REDUCTASE

ZINGIBER OFFICINALE

MEDICINAL PLANT

Abstract

Introduction: ZINGIBER OFFICINALE Roscoe, commonly known as ginger, is used as a cooking spice and therapeutically for its antioxidant and androgenic activities. We investigated the effects of Z. officinale hydro-alcoholic extract on HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase level in the testis of streptozotocin (STZ) -induced diabetic rats.Methods: The current experimental study was performed on four groups of male Wistar rats one of them was kept as a healthy control, while the others were rendered diabetic via a single intraperitoneal injection of STZ (60 mg kg-1). One group was considered as diabetic control; while the others were given orally hydro-alcoholic extract (200 and 400 mg kg-1) for 56 consecutive days. Body weight, blood glucose and insulin concentrations were evaluated using standard methods. The HMG-COA REDUCTASE level was determined by western blot analysis.Results: Treatment with the extract resulted in a significant reduction of serum glucose concentration and HMG-COA REDUCTASE level in the rat’s testis compared to diabetic controls (P<0.01). A significant increase in body weight was observed in treated diabetic rats. Also, serum insulin was significantly increased in diabetic rats treated with 400 mg/kg of the extract compared to diabetic controls (P<0.05).Conclusion: Ginger has a potential influence on the regulation of cholesterol homeostasis by modulating of HMG-COA REDUCTASE level. The results provide scientific evidence to confirm the traditional use of Z. officinale in the treatment of diabetes mellitus.

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References

EFFECTS OF THE HYDROALCOHOLIC EXTRACT OF ZINGIBER OFFICINALE ON ARGINASE I ACTIVITY AND EXPRESSION IN THE RETINA OF STREPTOZOTOCIN-INDUCED DIABETIC RATS

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APA: Copy

MORADI PODEH, BAHMAN, KHEIROLLAH, ALIREZA, AHMMADPOUR, FATEMEH, LAMUCHI DELI, NASRIN, PAYAMI, SEYEDE AREFE, & MOHAMMADZADEH, GHORBAN. (2018). EFFECTS OF ZINGIBER OFFICINALE HYDRO-ALCOHOLIC EXTRACT ON HMG-COA REDUCTASE LEVEL IN THE TESTIS OF STREPTOZOTOCIN-INDUCED DIABETIC RATS. JOURNAL OF HERBMED PHARMACOLOGY, 7(2 ), 94-99. SID. https://sid.ir/paper/343712/en

Vancouver: Copy

MORADI PODEH BAHMAN, KHEIROLLAH ALIREZA, AHMMADPOUR FATEMEH, LAMUCHI DELI NASRIN, PAYAMI SEYEDE AREFE, MOHAMMADZADEH GHORBAN. EFFECTS OF ZINGIBER OFFICINALE HYDRO-ALCOHOLIC EXTRACT ON HMG-COA REDUCTASE LEVEL IN THE TESTIS OF STREPTOZOTOCIN-INDUCED DIABETIC RATS. JOURNAL OF HERBMED PHARMACOLOGY[Internet]. 2018;7(2 ):94-99. Available from: https://sid.ir/paper/343712/en

IEEE: Copy

BAHMAN MORADI PODEH, ALIREZA KHEIROLLAH, FATEMEH AHMMADPOUR, NASRIN LAMUCHI DELI, SEYEDE AREFE PAYAMI, and GHORBAN MOHAMMADZADEH, “EFFECTS OF ZINGIBER OFFICINALE HYDRO-ALCOHOLIC EXTRACT ON HMG-COA REDUCTASE LEVEL IN THE TESTIS OF STREPTOZOTOCIN-INDUCED DIABETIC RATS,” JOURNAL OF HERBMED PHARMACOLOGY, vol. 7, no. 2 , pp. 94–99, 2018, [Online]. Available: https://sid.ir/paper/343712/en

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