PREIMPLANTATION GENETIC DIAGNOSIS (PGD), IMPORTANCE, APPLICATIONS AND ITS PROSPECTIVES

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NOURI DALOUEI M.R.; RASHIDINEZHAD A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: Medicine and Spiritual Cultivation Year:2008 | Volume:16 | Issue:3-4 (66-67) Page(s): 70-89

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Title

PREIMPLANTATION GENETIC DIAGNOSIS (PGD), IMPORTANCE, APPLICATIONS AND ITS PROSPECTIVES

Author(s)

NOURI DALOUEI M.R. | RASHIDINEZHAD A. | Issue Writer Certificate

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Abstract

Preimplantation genetic diagnosis (PGD) is an evolving technique that provides a practical alternative to prenatal diagnosis and termination of pregnancy for couples who are at substantial risk of transmitting a serious genetic disorder to their offspring. Since the first application of PGD in 1989, it has been expanded in scope and applications. Fluorescence in situ hybridization has been introduced for the analysis of chromosomes and PCR for the analysis genes for in cases of monogenic disorders. PGD involves assisted reproductive technologies even though most couples undertaking it are fertile. Early PGD protocols used blastomer biopsied from cleavage stage embryos but testing of first and second polar bodies is now a routine alternative, and blastocyst biopsy can also be used. More recently, FISH technology has been harnessed to provide PGD-AS, or aneuploidy screening, with the aim of replacing euploid embryos and increasing pregnancy rates in groups of women who have poor IVF success rates. More recent application of PGD in areas such as HLA typing and social sex selection have stoked public controversy and concern, while providing interesting ethical debates and keeping PGD firmly in the public eyes. Here, we provide and overview of indications for, techniques used in, some advantage and disadvantages of PGD.

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APA: Copy

NOURI DALOUEI, M.R., & RASHIDINEZHAD, A.. (2008). PREIMPLANTATION GENETIC DIAGNOSIS (PGD), IMPORTANCE, APPLICATIONS AND ITS PROSPECTIVES. TEB VA TAZKIEH, 16(3-4 (66-67)), 70-89. SID. https://sid.ir/paper/34374/en

Vancouver: Copy

NOURI DALOUEI M.R., RASHIDINEZHAD A.. PREIMPLANTATION GENETIC DIAGNOSIS (PGD), IMPORTANCE, APPLICATIONS AND ITS PROSPECTIVES. TEB VA TAZKIEH[Internet]. 2008;16(3-4 (66-67)):70-89. Available from: https://sid.ir/paper/34374/en

IEEE: Copy

M.R. NOURI DALOUEI, and A. RASHIDINEZHAD, “PREIMPLANTATION GENETIC DIAGNOSIS (PGD), IMPORTANCE, APPLICATIONS AND ITS PROSPECTIVES,” TEB VA TAZKIEH, vol. 16, no. 3-4 (66-67), pp. 70–89, 2008, [Online]. Available: https://sid.ir/paper/34374/en

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