Introduction: Most of authorities consider cigarette smoking as the first step towards other abused substance consumption in young population. Although the studies on relationship between health and religion is still in the infancy stage, but a remarkable increase in the number of the studies which have been conducted to assess the relationship between religious bounds and cigarette smoking, can be seen especially in Christians. As a result we carried out a study to determine the prevalence of cigarette smoking in a group of Iranian Muslim students. Also the relationship between the religious practices and cigarette smoking was assessed.Methods: In this cross-sectional study 950 students in one of the kerman universities, were asked to fill self administered questionnaire, without Identity and contained some demographic information and questions on cigarette smoking and religious practices. Either daily smoker or occasional smokers were defined as cigarette smokers. As religion is a multi-dimensional concept, the participants were asked about their mosque attendance, obligatory religious practices (saying prayer and fasting) and reading Koran. Logistic regression was applied to assess the relationship between predictor variables (religious measures) and cigarette smoker. Result: Considering the left 833 questionnaire went under final analysis 54.1% were female, 89.3% were single, 129 were college students while others had higher education (84.5%) and all were Muslims. 17% were occasional smokers whereas 4.5% were daily smokers. 40.1% of male students and 5.8% of female students were smokers. The average age of starting smoking was 16.8±3.5 and 68.6% started smoking before 18. Performing single variable Analysis, a significant difference was detected in prevalence of smokers considering these studied variables: gender, marital status, salary per month, average of scores, smoker friends, smoker parents and family, reading Koran, saying prayer, mosque attendance, fasting. But using multi variable analysis, only 4 variables: gender, average of scores, cigarette consumption by friends and saying prayer, remained in the model. Conclusion: Overcoming the anger and depression were considered as the most Important causes to smoke cigarette in students points of view. As a consequence in this study cigarette consumption in friends was defined as a risk factor. And a protective role was shown for saying prayer.