IDENTIFICAION OF A FACTOR INHIBITING PROSTATE CANCER CELL LINE (LNCAP)

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ABOU ALHASANI MOHSEN

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Journal: Medicine and Spiritual Cultivation Year:2004 | Volume:- | Issue:51 Page(s): 10-16

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Information Journal Paper

Title

IDENTIFICAION OF A FACTOR INHIBITING PROSTATE CANCER CELL LINE (LNCAP)

Author(s)

ABOU ALHASANI MOHSEN | Issue Writer Certificate

Keywords

PROSTATE CANCERQ2

ANTI GROWTH FACTORQ4

CANCER CELLS DU-145Q3

PC3Q4

LNCAPQ3

Abstract

A new antiproliferative activity from the conditional medium of two androgen-independent prostatic cancer cell lines, PC3 and DU-145, was identified. This antiproliferative activity selectively inhibited cell proliferation of an androgen-dependent PROSTATE CANCER cell line LNCAP in a dose dependent manner. No antiproliferative activity was observed against mouse fibro blast 3T3, normal human lymphocytes, human leukemic cells including promyelocytes HL-6 and T-cells HUT-78, or human adenocarcinoma cell lines, including prostatic cells JCA-1 ovary NIH: OVCAR-3, cervix C-33A and breast MDA-MB-231. Cell cycle analysis revealed that the antiproliferative activity did not induce apoptosis in LNCAP cells, but it prevented some of G1 LNCAP cells from entering into the S-Phase of the cell cycle. The antiproliferative activity was sensitive to protease digestion and its approximate molecular weight was between 50-100 kDa by Amicon filters. The antiproliferative activity was not affected by neutralizing antibodies against TGF- b1,2,3 TNF-a, PDGF, EGF, IL-1 IL-2. IL-3, IL-4, or IL-6.

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APA: Copy

ABOU ALHASANI, MOHSEN. (2004). IDENTIFICAION OF A FACTOR INHIBITING PROSTATE CANCER CELL LINE (LNCAP). TEB VA TAZKIEH, -(51), 10-16. SID. https://sid.ir/paper/34406/en

Vancouver: Copy

ABOU ALHASANI MOHSEN. IDENTIFICAION OF A FACTOR INHIBITING PROSTATE CANCER CELL LINE (LNCAP). TEB VA TAZKIEH[Internet]. 2004;-(51):10-16. Available from: https://sid.ir/paper/34406/en

IEEE: Copy

MOHSEN ABOU ALHASANI, “IDENTIFICAION OF A FACTOR INHIBITING PROSTATE CANCER CELL LINE (LNCAP),” TEB VA TAZKIEH, vol. -, no. 51, pp. 10–16, 2004, [Online]. Available: https://sid.ir/paper/34406/en

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