Histopathological Pattern of Difficult Childhood Nephrotic Syndrome in a Tertiary Care Centre, Bangladesh

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Roy Ranjit Ranjan; Rahman Farhana; Arju Jahanara; Sultana Jakia; Chaki Agomoni; Akter Amina; Mamun Abdullah Al; Jesmin Tahmina; Haque Sayed Saimul; Begum Afroza; Muin Uddin Golam; Rahman Md. Habibur

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Journal: JOURNAL OF PEDIATRIC NEPHROLOGY Year:2019 | Volume:7 | Issue:3 Page(s): 0-0

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Title

Histopathological Pattern of Difficult Childhood Nephrotic Syndrome in a Tertiary Care Centre, Bangladesh

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Keywords

Nephrotic Syndrome

Focal Segmental Glomerulosclerosis

Chronic kidney disease (CDK)

Child

Abstract

Background and Aim: The aim of this study was to explore the spectrum of histopathology in Children who underwent a renal biopsy for difficult NS in a tertiary care pediatric nephrology center. Methods: This prospective observational study was conducted in the Pediatric Nephrology Department of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from January 2011 to July 2018. Patients who presented with difficult patterns of Nephrotic Syndrome and underwent a renal biopsy were enrolled in this study. Results: A total of 140 patients were recruited in this study. The patients with steroid resistance Nephrotic Syndrome (SRNS) and Nephrotic Syndrome with atypical presentation underwent a renal biopsy; a good number of atypical NS cases were steroid dependent Nephrotic Syndrome (SDNS). They were grouped into Group A (SRNS), Group B (SDNS) and Group C (Nephrotic Syndrome with atypical presentation). In patients with SDNS, minimal change disease (MCD) (51. 3%) was the most common histological pattern followed by mesangioproliferative glomerulonephritis (MesPGN) (33. 3%); whereas MesPGN was the commonest histological pattern in SRNS (56. 8%) and Nephrotic Syndrome with atypical presentation (54. 7%) followed by MCD and Focal Segmental Glomerulosclerosis (FSGS). Most of the patients responded to immunosuppressive therapy. In SRNS, a partial response was achieved in 18. 9% and chronic kidney diseases (CKD) occurred in 16. 2% of the cases. In comparison, 10. 9% of the patients with Nephrotic Syndrome with atypical presentation achieved partial response and 7. 8% developed CKD, which were not statistically significant. In addition, 5. 4% of the patients with SRNS died. Conclusion: Mesangioproliferative glomerulonephritis was the most common histopathological diagnosis in patients with SRNS and Nephrotic Syndrome atypical presentation in our population. MCD was predominant in SDNS cases.

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APA: Copy

Roy, Ranjit Ranjan, Rahman, Farhana, Arju, Jahanara, Sultana, Jakia, Chaki, Agomoni, Akter, Amina, Mamun, Abdullah Al, Jesmin, Tahmina, Haque, Sayed Saimul, Begum, Afroza, Muin Uddin, Golam, & Rahman, Md. Habibur. (2019). Histopathological Pattern of Difficult Childhood Nephrotic Syndrome in a Tertiary Care Centre, Bangladesh. JOURNAL OF PEDIATRIC NEPHROLOGY, 7(3), 0-0. SID. https://sid.ir/paper/344468/en

Vancouver: Copy

Roy Ranjit Ranjan, Rahman Farhana, Arju Jahanara, Sultana Jakia, Chaki Agomoni, Akter Amina, Mamun Abdullah Al, Jesmin Tahmina, Haque Sayed Saimul, Begum Afroza, Muin Uddin Golam, Rahman Md. Habibur. Histopathological Pattern of Difficult Childhood Nephrotic Syndrome in a Tertiary Care Centre, Bangladesh. JOURNAL OF PEDIATRIC NEPHROLOGY[Internet]. 2019;7(3):0-0. Available from: https://sid.ir/paper/344468/en

IEEE: Copy

Ranjit Ranjan Roy, Farhana Rahman, Jahanara Arju, Jakia Sultana, Agomoni Chaki, Amina Akter, Abdullah Al Mamun, Tahmina Jesmin, Sayed Saimul Haque, Afroza Begum, Golam Muin Uddin, and Md. Habibur Rahman, “Histopathological Pattern of Difficult Childhood Nephrotic Syndrome in a Tertiary Care Centre, Bangladesh,” JOURNAL OF PEDIATRIC NEPHROLOGY, vol. 7, no. 3, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/344468/en

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