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Information Journal Paper

Title

Protective Effect of Ghrelin on Oxidative Stress and Tissue Damages of Mice Testes Followed by Chemotherapy With Cyclophosphamide

Pages

  138-143

Abstract

 Objectives: Cyclophosphamide (CP) is one of the common medications used as Chemotherapy and immune-suppressive agent in organ transplantation. Despite numerous clinical applications of this drug in cancer treatment, it causes adverse effects on body tissues, especially the male reproductive organs by increasing Oxidative stress. The present study aimed to analyze the effects of Ghrelin, as an antioxidant substance, on testicular damages induced by CP. Materials and Methods: Forty male mice were randomly divided into 4 groups: 1) control; 2) CP; 3) CP + Ghrelin; and 4) Ghrelin. CP (100 mg/kg body weight) was injected intraperitoneally once a week and Ghrelin (80 μ g/kg body weight) was administered daily for 5 weeks. After 5 weeks, the testicles were removed and we investigated histological changes and testicular Oxidative stress markers including malondialdehyde, superoxide dismutase, glutathione peroxidase, and total antioxidant capacity. Results: Our results showed that CP increased malondialdehyde level and decreased glutathione peroxidase, superoxide dismutase, and the total antioxidant capacity (P < 0. 05). Furthermore, degenerative changes in the testicular tissue were observed in CP group. The aforementioned factors were improved in the group that was treated with Ghrelin (P < 0. 05). Conclusions: The results of this study revealed that Ghrelin decreases the damages caused by CP in testicular tissue of mice by reducing lipid peroxidation and increasing total antioxidant capacity.

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    APA: Copy

    Salimnejad, Ramin, SOLEIMANI RAD, JAFAR, & MOHAMMAD NEJAD, DARYOUSH. (2018). Protective Effect of Ghrelin on Oxidative Stress and Tissue Damages of Mice Testes Followed by Chemotherapy With Cyclophosphamide. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, 5(2), 138-143. SID. https://sid.ir/paper/344991/en

    Vancouver: Copy

    Salimnejad Ramin, SOLEIMANI RAD JAFAR, MOHAMMAD NEJAD DARYOUSH. Protective Effect of Ghrelin on Oxidative Stress and Tissue Damages of Mice Testes Followed by Chemotherapy With Cyclophosphamide. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES[Internet]. 2018;5(2):138-143. Available from: https://sid.ir/paper/344991/en

    IEEE: Copy

    Ramin Salimnejad, JAFAR SOLEIMANI RAD, and DARYOUSH MOHAMMAD NEJAD, “Protective Effect of Ghrelin on Oxidative Stress and Tissue Damages of Mice Testes Followed by Chemotherapy With Cyclophosphamide,” CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, vol. 5, no. 2, pp. 138–143, 2018, [Online]. Available: https://sid.ir/paper/344991/en

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