HIGH FAT DIET- INDUCED NEUROTOXICITY ALTERS FOLLOWING VITAMIN E AND C ADMINISTRATION IN HIPPOCAMPUS OF MALE RATS

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SALEHI IRAJ; SAIDIJAM MASSOUD; VAHIDINIA ALIASGHAR; SOHRABI MARYAM; SOLEIMANI ASL SARA

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Journal: Gene, Cell and Tissue Year:2017 | Volume:4 | Issue:4 Page(s): 0-0

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Title

HIGH FAT DIET- INDUCED NEUROTOXICITY ALTERS FOLLOWING VITAMIN E AND C ADMINISTRATION IN HIPPOCAMPUS OF MALE RATS

Author(s)

Keywords

DIET

HIGH-FAT

APOPTOSIS

NEUROTROPHIC FACTOR

ANTIOXIDANT

Abstract

Background: Consumption of a high fat DIET (HFD) leads to spatial memory impairment and hippocampal cell death.Objectives: The present study evaluated the capacity of ANTIOXIDANT supplementation to interact with the effects of high fat DIET at the molecular level.Methods: Animal groups were exposed to HFD for 9 months with free access to high fat DIET and high fat DIET with ANTIOXIDANT supplementation (vitamin E, vitamin C, andAstaxanthin). At the endof the study, brains wereremovedandthe level of brain-derived NEUROTROPHIC FACTOR (BDNF), Tropomyosin receptor kinase B (Trk b), synapsin I, and the transcription factor Cyclic AMP Response Element Binding protein (CREB) and caspase-3 expression in the hippocampi were measured.Results: ANTIOXIDANTs protected against HFD-induced cell death and the up-regulation of BDNF, Trk b, Synapsin I, CREB, and Caspase-3.Conclusions: This data suggested the possible benefit of vitamin E and C in the treatment of neurotoxicity among, those with a HFD.

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APA: Copy

SALEHI, IRAJ, SAIDIJAM, MASSOUD, VAHIDINIA, ALIASGHAR, SOHRABI, MARYAM, & SOLEIMANI ASL, SARA. (2017). HIGH FAT DIET- INDUCED NEUROTOXICITY ALTERS FOLLOWING VITAMIN E AND C ADMINISTRATION IN HIPPOCAMPUS OF MALE RATS. GENE, CELL AND TISSUE, 4(4), 0-0. SID. https://sid.ir/paper/345137/en

Vancouver: Copy

SALEHI IRAJ, SAIDIJAM MASSOUD, VAHIDINIA ALIASGHAR, SOHRABI MARYAM, SOLEIMANI ASL SARA. HIGH FAT DIET- INDUCED NEUROTOXICITY ALTERS FOLLOWING VITAMIN E AND C ADMINISTRATION IN HIPPOCAMPUS OF MALE RATS. GENE, CELL AND TISSUE[Internet]. 2017;4(4):0-0. Available from: https://sid.ir/paper/345137/en

IEEE: Copy

IRAJ SALEHI, MASSOUD SAIDIJAM, ALIASGHAR VAHIDINIA, MARYAM SOHRABI, and SARA SOLEIMANI ASL, “HIGH FAT DIET- INDUCED NEUROTOXICITY ALTERS FOLLOWING VITAMIN E AND C ADMINISTRATION IN HIPPOCAMPUS OF MALE RATS,” GENE, CELL AND TISSUE, vol. 4, no. 4, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/345137/en

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