Association of Genetic Variations in XRCC1 and ERCC1 Genes with Sporadic Breast Cancer

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GHORBIAN SAEID; Nargesian Mansooreh; TALANEH SASAN; Asnaashari Omid; SHARIFI RASUL

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Journal: Gene, Cell and Tissue Year:2018 | Volume:5 | Issue:2 Page(s): 0-0

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Title

Association of Genetic Variations in XRCC1 and ERCC1 Genes with Sporadic Breast Cancer

Author(s)

Keywords

XRCC1

Breast Cancer

ERCC1

DNA Repair

Abstract

Background: Recently, findings have validated the significant role of DNA damage genes related to the pathogenesis of Breast Cancer (BC). The aim of the present investigation was to evaluate possibility roles of two common XRCC1 (rs25487; A > G) and ERCC1 (rs3212964; A > G) gene polymorphisms with the risk of sporadic BC. Methods: In a case-control study, consisting of 100 females identified with sporadic BC and 100 malignancy-free females as the control group. We used Tetra-ARMS Polymerase Chain Reaction (PCR) and PCR-Restriction Fragment Length Polymorphism (RFLP) methods to determine genotype frequencies of XRCC1 and ERCC1 genes. Results: The findings did not reveal a statistically significant difference in the genotype frequencies of XRCC1 and ERCC1 genes between the two groups (P > 0. 05). The frequency of G mutant allele for XRCC1 and ERCC genes was higher in cases compared to controls, while the difference between the groups was not statistically significant (P = 0. 202; OR: 1. 312; CI: 0864-1. 994), (P = 0. 352; OR: 1. 213; CI: 0. 808-1. 820). Conclusions: The current results provide evidence against the hypothesis that XRCC1 (rs25487) and ERCC1 (rs3212964) gene polymorphisms may be associated with a predisposition to sporadic BC.

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APA: Copy

GHORBIAN, SAEID, Nargesian, Mansooreh, TALANEH, SASAN, Asnaashari, Omid, & SHARIFI, RASUL. (2018). Association of Genetic Variations in XRCC1 and ERCC1 Genes with Sporadic Breast Cancer. GENE, CELL AND TISSUE, 5(2), 0-0. SID. https://sid.ir/paper/345189/en

Vancouver: Copy

GHORBIAN SAEID, Nargesian Mansooreh, TALANEH SASAN, Asnaashari Omid, SHARIFI RASUL. Association of Genetic Variations in XRCC1 and ERCC1 Genes with Sporadic Breast Cancer. GENE, CELL AND TISSUE[Internet]. 2018;5(2):0-0. Available from: https://sid.ir/paper/345189/en

IEEE: Copy

SAEID GHORBIAN, Mansooreh Nargesian, SASAN TALANEH, Omid Asnaashari, and RASUL SHARIFI, “Association of Genetic Variations in XRCC1 and ERCC1 Genes with Sporadic Breast Cancer,” GENE, CELL AND TISSUE, vol. 5, no. 2, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/345189/en

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