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Title

TUBERCULOSIS AND VITAMIN D STATUS AMONG THE CONTACTS OF PULMONARY TUBERCULOSIS PATIENTS

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Abstract

 Background: Serum VITAMIN D (VitD) status is associated with active TUBERCULOSIS (TB) and TB infection conversion (TBIC).Objectives: The objective of the present study was to quantify the risks of TB (latent, conversion, disease) in accordance with VitD status and other variables among the contacts of pulmonary TB patients.Methods: From 2009 to 2012, a cohort of the contacts of pulmonary TB patients was studied to rule out and prevent TB in Castellon (Spain). The exams performed included a tuberculin skin test (TST), a QuantiFERON Gold in-tube test® (QFTGIT), blood and radiographic tests, and an initial measurement of serum VitD status. Contacts who were initially without active TB were followed up through 2015. Multinomial logistic regression (MLR) analyses were carried out.Results: From a total of 572 contacts of pulmonary TB patients with VitD status measurement, 523 completed the follow-up (participation rate 91.4%). Among them, five groups could be established: 3 new cases of pulmonary TB (0.6%), 27 cases of TBIC (5.2%), 116 cases of latent TB infection (LTBI) (22.2%), 125 uninfected TB contacts with only one TST or QFTGIT measurement (23.9%), and 252 uninfected TB contacts with two TST or QFTGIT measurements (48.2%). The comparison of these five groups revealed several significant differences, including age, whether they were foreign-born, place of residence, social class, high exposure to an index case with sputum acid-fast bacilli (AFB), and VitD status. The MLR analysis for all groups, with the group of uninfected TB contacts with two TST or QFTGIT measurements as a reference, estimated that only two of these factors were significantly associated with TB in three or more groups; these factors were VitD status and high exposure and a sputum AFB-positive index case. VitD status was a protector against pulmonary TB with a relative risk (RR) of 0.86 (95% confidence interval [CI] 0.74 - 0.99) and against TBIC (R=0.95; 95% CI 0.91- 0.99), while it was not associated with LTBI (RR=0.99; 95% CI 0.97-1.01). Only 34.0% of the contacts had sufficient VitD levels ( 30 ng/mL).Conclusions: Our results suggest that a sufficient VitD level could be a protective factor against TBIC and active TB.

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APA: Copy

ARNEDO PENA, ALBERTO, JUAN CERDAN, JOSE VICENTE, ROMEU GARCIA, MARIA ANGELES, GARCIA FERRER, DANIEL, IBORRA MILLET, JESUS, FERRERO VEGA, JOSE ANTONIO, BELLIDO BLASCO, JUAN BAUTISTA, MESEGUER FERRER, NOEMI, & PARDO SERRANO, FRANCISCO. (). . , (), -. SID. https://sid.ir/paper/346826/en

Vancouver: Copy

ARNEDO PENA ALBERTO, JUAN CERDAN JOSE VICENTE, ROMEU GARCIA MARIA ANGELES, GARCIA FERRER DANIEL, IBORRA MILLET JESUS, FERRERO VEGA JOSE ANTONIO, BELLIDO BLASCO JUAN BAUTISTA, MESEGUER FERRER NOEMI, PARDO SERRANO FRANCISCO. . [Internet]. ;():-. Available from: https://sid.ir/paper/346826/en

IEEE: Copy

ALBERTO ARNEDO PENA, JOSE VICENTE JUAN CERDAN, MARIA ANGELES ROMEU GARCIA, DANIEL GARCIA FERRER, JESUS IBORRA MILLET, JOSE ANTONIO FERRERO VEGA, JUAN BAUTISTA BELLIDO BLASCO, NOEMI MESEGUER FERRER, and FRANCISCO PARDO SERRANO, “,” , vol. , no. , pp. –, , [Online]. Available: https://sid.ir/paper/346826/en

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