THE ASSOCIATION OF SUBCLINICAL HYPOTHYROIDISM AND PATTERN OF CIRCULATING ENDOTHELIAL-DERIVED MICROPARTICLES AMONG CHRONIC HEART FAILURE PATIENTS

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BEREZIN ALEXANDER E.; KREMZER ALEXANDER A.; MARTOVITSKAYA YULIA V.; SAMURA TATYANA A.; BEREZINA TATYANA A.

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Journal: RESEARCH IN CARDIOVASCULAR MEDICINE Year:2015 | Volume:4 | Issue:4 Page(s): 0-0

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Title

THE ASSOCIATION OF SUBCLINICAL HYPOTHYROIDISM AND PATTERN OF CIRCULATING ENDOTHELIAL-DERIVED MICROPARTICLES AMONG CHRONIC HEART FAILURE PATIENTS

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Keywords

CHRONIC HEART FAILURE

MICROPARTICLES

THYROID DYSFUNCTION

Abstract

Background: Subclinical hypothyroidism (SH) is diagnosed biochemically by the presence of normal serum free thyroxine concentration, in conjunction with an elevated serum thyroid-stimulating hormone level. Recent studies have demonstrated the frequent association between SH and cardiovascular diseases and risk factors.Objectives: To evaluate the impact of SH on patterns of circulating endothelial-derived MICROPARTICLES, (EMPs) among CHRONIC HEART FAILURE (CHF) patientsPatients and Methods: This is a retrospective study involving a cohort of 388 patients with CHF. Fifty-three CHF subjects had SH and 335 patients were free from THYROID DYSFUNCTION. Circulating levels of N-terminal-pro brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hs-CRP), thyroid-stimulating hormone (TSH), total and free thyroxine (T4), and triiodothyronine (T3), and endothelial apoptotic MICROPARTICLES (EMPs), were measured at baseline. SH was defined, according to contemporary clinical guidelines, as a biochemical state associated with an elevated serum TSH level of greater 10 mU/L and normal basal free T3 and T4 concentrations.Results: Circulating CD31+/annexin V+ EMPs were higher in patients with SH compared to those without SH. In contrast, activated CD62E+ EMP numbers were not significantly different between both patient cohorts. Using uni (bi) variate and multivariate age- and gender-adjusted regression analysis, we found several predictors that affected the increase of the CD31+/annexin V+ to CD62E+ ratio in the patient study population. The independent impact of TSH per 6.5 mU/L (odds ratio [OR]=1.23, P=0.001), SH (OR=1.22, P=0.001), NT-proBNP (OR=1.19, P=0.001), NYHA class (OR=1.09, P=0.001), hs-CRP per 4.50 mg/L (OR = 1.05, P = 0.001), dyslipidemia (OR=1.06, P=0.001), serum uric acid per 9.5 mmol/L (OR=1.04, P=0.022) on the increase in the CD31+/annexin V+ to CD62E+ ratio, was determined.Conclusions: We believe that the SH state in CHF patients may be associated with the impaired pattern of circulating EMPs, with the predominantly increased number of apoptotic-derived MICROPARTICLES.

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APA: Copy

BEREZIN, ALEXANDER E., KREMZER, ALEXANDER A., MARTOVITSKAYA, YULIA V., SAMURA, TATYANA A., & BEREZINA, TATYANA A.. (2015). THE ASSOCIATION OF SUBCLINICAL HYPOTHYROIDISM AND PATTERN OF CIRCULATING ENDOTHELIAL-DERIVED MICROPARTICLES AMONG CHRONIC HEART FAILURE PATIENTS. RESEARCH IN CARDIOVASCULAR MEDICINE, 4(4), 0-0. SID. https://sid.ir/paper/346940/en

Vancouver: Copy

BEREZIN ALEXANDER E., KREMZER ALEXANDER A., MARTOVITSKAYA YULIA V., SAMURA TATYANA A., BEREZINA TATYANA A.. THE ASSOCIATION OF SUBCLINICAL HYPOTHYROIDISM AND PATTERN OF CIRCULATING ENDOTHELIAL-DERIVED MICROPARTICLES AMONG CHRONIC HEART FAILURE PATIENTS. RESEARCH IN CARDIOVASCULAR MEDICINE[Internet]. 2015;4(4):0-0. Available from: https://sid.ir/paper/346940/en

IEEE: Copy

ALEXANDER E. BEREZIN, ALEXANDER A. KREMZER, YULIA V. MARTOVITSKAYA, TATYANA A. SAMURA, and TATYANA A. BEREZINA, “THE ASSOCIATION OF SUBCLINICAL HYPOTHYROIDISM AND PATTERN OF CIRCULATING ENDOTHELIAL-DERIVED MICROPARTICLES AMONG CHRONIC HEART FAILURE PATIENTS,” RESEARCH IN CARDIOVASCULAR MEDICINE, vol. 4, no. 4, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/346940/en

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