Tadalafil and Exercise Capacity after Fontan Operation

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHAJALI ZAHRA; PEIGHAMBARI MOHAMMAD MEHDI; LOTFIAN SARA; Golari maryam; Galeshi Bahar; Rouhani Morteza; ALIZADEH ZAHRA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: RESEARCH IN CARDIOVASCULAR MEDICINE Year:2018 | Volume:7 | Issue:2 Page(s): 64-68

Download Full-Text

View:

244

Download:

144

Cites:

Information Journal Paper

Title

Tadalafil and Exercise Capacity after Fontan Operation

Author(s)

Keywords

Exercise

Fontan surgery

single ventricle

tadalafil

Abstract

Background: Patients with congenital heart defects that have single functional ventricle undergo Fontan surgery. After the surgery, patients will develop reduced capacity for physical activity and Exercise. Phosphodiesterase inhibitor drugs have vasodilatory effects and can decrease blood flow resistance. Thereby, they can help to improve the Exercise capacity of patients. The aim of this study was to assess the effect of tadalafil on Exercise capacity in these patients. Materials and Methods: In this before and after interventional study, 16 patients who had undergone Fontan operation were treated with tadalafil (10 mg daily for 2 weeks and then 10 mg every 12 h for 6 months). Demographic data, heart disease morphology, pulse oximetry, blood pressure (BP), functional class, age at the time of surgery, and the surgery type were collected. Pulmonary function and Exercise capacity were assessed by 6‑ min walk test and VO2 max (maximal oxygen consumption). Results: Mean distance based on 6‑ min walk test increased from 418. 75 m to 439. 06 m (P = 0. 004). Mean maximal oxygen consumption increased from 0. 84 L/min to 1. 07 L/min (P < 0. 001). Furthermore, preExercise test oxygen saturation increased from 89% to 90. 94% (P = 0. 02). No significant change was observed regarding other variables. Conclusion: tadalafil was found to be effective in improving Exercise capacity of the patients with a previous history of Fontan surgery. However, tadalafil had no significant effect on systolic or diastolic BP and heart rate.

Cites

No record.

References

No record.

Cite

APA: Copy

KHAJALI, ZAHRA, PEIGHAMBARI, MOHAMMAD MEHDI, LOTFIAN, SARA, Golari, maryam, Galeshi, Bahar, Rouhani, Morteza, & ALIZADEH, ZAHRA. (2018). Tadalafil and Exercise Capacity after Fontan Operation. RESEARCH IN CARDIOVASCULAR MEDICINE, 7(2), 64-68. SID. https://sid.ir/paper/347004/en

Vancouver: Copy

KHAJALI ZAHRA, PEIGHAMBARI MOHAMMAD MEHDI, LOTFIAN SARA, Golari maryam, Galeshi Bahar, Rouhani Morteza, ALIZADEH ZAHRA. Tadalafil and Exercise Capacity after Fontan Operation. RESEARCH IN CARDIOVASCULAR MEDICINE[Internet]. 2018;7(2):64-68. Available from: https://sid.ir/paper/347004/en

IEEE: Copy

ZAHRA KHAJALI, MOHAMMAD MEHDI PEIGHAMBARI, SARA LOTFIAN, maryam Golari, Bahar Galeshi, Morteza Rouhani, and ZAHRA ALIZADEH, “Tadalafil and Exercise Capacity after Fontan Operation,” RESEARCH IN CARDIOVASCULAR MEDICINE, vol. 7, no. 2, pp. 64–68, 2018, [Online]. Available: https://sid.ir/paper/347004/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops