PHYLOGENETIC GROUPING AND ASSESSMENT OF VIRULENCE GENOTYPES, WITH ANTIBIOTIC RESISTANCE PATTERNS, OF ESCHERICHIA COLI STRAINS IMPLICATED IN FEMALE URINARY TRACT INFECTIONS

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STAJI HAMID; KHOSHGOFTAR JAVAD; JAVAHERI VAYEGHAN ABBAS; SALIMI BEJESTANI MOHAMMAD REZA

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Journal: International Journal of Enteric Pathogens Year:2016 | Volume:4 | Issue:1 Page(s): 16-22

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Title

PHYLOGENETIC GROUPING AND ASSESSMENT OF VIRULENCE GENOTYPES, WITH ANTIBIOTIC RESISTANCE PATTERNS, OF ESCHERICHIA COLI STRAINS IMPLICATED IN FEMALE URINARY TRACT INFECTIONS

Author(s)

STAJI HAMID | KHOSHGOFTAR JAVAD | JAVAHERI VAYEGHAN ABBAS | SALIMI BEJESTANI MOHAMMAD REZA | Issue Writer Certificate

Keywords

ANTIBIOTIC RESISTANCE

FEMALE

URINARY TRACT INFECTIONS

VIRULENCE FACTORS

ESCHERICHIA COLI

Abstract

Background: ESCHERICHIA COLI strains are common pathogens that can cause URINARY TRACT INFECTIONS (UTIs). They are classified intophylogroups based on three genetic markers: chuA, yjaA, and TspE4.C2. The E. coli strains that cause UTIs possess several genes that encodeurovirulent factors and antimicrobial-resistance phenotypes. We determined the phylogenetic groups of E. coli isolates from UTI cases inSabzevar, Iran, the prevalence of certain virulence genes, and the antibiotic-resistance phenotypes in these strains.Objectives: The aim of this study was to assess the correlation of detected E. coli phylogroups in FEMALE UTI patients with the antibioticresistance pattern and the distribution of certain VIRULENCE FACTORS among the phylogroups.Materials and Methods: Ninety-three E. coli isolates from 150 women with UTI were studied. Three genetic markers were detected forphylogenetic grouping of strains, and four virulence determinants were analyzed with multiplex-PCR, including the genes for hemolysin (hly), aerobactin (iucD), P fimbriae (pap), and S/F1C fimbriae (sfa/focDE). The antibiotic-resistance phenotypes were also determined.Results: The isolates from UTI cases were distributed within phylogroups A (31%), B 1 (10%), B 2 (28%), and D (31%). The prevalence of iucD, hly, pap, and sfa/focDE virulence genes was significantly associated with groups B 2 and D. The most-resisted antibiotics were cefazolin (93%) andco-trimoxazole (68%), while the isolates were most sensitive to nitrofurantoin (1%) and imipenem (2%).Conclusions: The phylogroups of E. coli isolates from UTI cases showed that groups D, B 2, and A are prevalent in women in Sabzevar, asthe dominant pathogenic phylogroups. The comparison showed that there was no significant difference in the occurrence of virulencefactors or in the distribution of ANTIBIOTIC RESISTANCE between urinary E. coli isolates, but the virulence genes were distributed more intogroups B 2 and D, respectively. Our study showed that the highest sensitivity was to nitrofurantoin and imipenem, but the decision on atreatment strategy remains based on the physician’s diagnosis and the antimicrobial-resistance tests.

Cites

Comparative virulotyping and phylogenomics of Escherichia coli isolates from urine samples of men and women suffering urinary tract infections

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APA: Copy

STAJI, HAMID, KHOSHGOFTAR, JAVAD, JAVAHERI VAYEGHAN, ABBAS, & SALIMI BEJESTANI, MOHAMMAD REZA. (2016). PHYLOGENETIC GROUPING AND ASSESSMENT OF VIRULENCE GENOTYPES, WITH ANTIBIOTIC RESISTANCE PATTERNS, OF ESCHERICHIA COLI STRAINS IMPLICATED IN FEMALE URINARY TRACT INFECTIONS. INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN, 4(1), 16-22. SID. https://sid.ir/paper/347497/en

Vancouver: Copy

STAJI HAMID, KHOSHGOFTAR JAVAD, JAVAHERI VAYEGHAN ABBAS, SALIMI BEJESTANI MOHAMMAD REZA. PHYLOGENETIC GROUPING AND ASSESSMENT OF VIRULENCE GENOTYPES, WITH ANTIBIOTIC RESISTANCE PATTERNS, OF ESCHERICHIA COLI STRAINS IMPLICATED IN FEMALE URINARY TRACT INFECTIONS. INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN[Internet]. 2016;4(1):16-22. Available from: https://sid.ir/paper/347497/en

IEEE: Copy

HAMID STAJI, JAVAD KHOSHGOFTAR, ABBAS JAVAHERI VAYEGHAN, and MOHAMMAD REZA SALIMI BEJESTANI, “PHYLOGENETIC GROUPING AND ASSESSMENT OF VIRULENCE GENOTYPES, WITH ANTIBIOTIC RESISTANCE PATTERNS, OF ESCHERICHIA COLI STRAINS IMPLICATED IN FEMALE URINARY TRACT INFECTIONS,” INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN, vol. 4, no. 1, pp. 16–22, 2016, [Online]. Available: https://sid.ir/paper/347497/en

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