ASSESSMENT THE OF AMPLIFICATION HER-2/NEU GENE BY CHROMOGENIC IN SITU HYBRIDIZATION (CISH) COMPARED TO IMMUNOHISTOCHEMISTRY (IHC) METHOD IN GASTRIC CANCER

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AMOUEIAN SAKINEH; ATTARANZADEH ARMIN; MONTAZER MEHDI; AKHAVAN REZAYAT ARASH; BEHFOROUZ AMIR; SOBHANI FATEMEH

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Journal: RAZAVI INTERNATIONAL JOURNAL OF MEDICINE Year:2018 | Volume:6 | Issue:1 Page(s): 0-0

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Title

ASSESSMENT THE OF AMPLIFICATION HER-2/NEU GENE BY CHROMOGENIC IN SITU HYBRIDIZATION (CISH) COMPARED TO IMMUNOHISTOCHEMISTRY (IHC) METHOD IN GASTRIC CANCER

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Keywords

STOMACH NEOPLASMS

IMMUNOHISTOCHEMISTRY

CHROMOGENIC IN SITU HYBRIDIZATION

ERBB-2

HER2/NEU

Abstract

Background: Gastric cancer has a high mortality rate and often has a poor treatment outcome. The HER2/NEU gene target therapy has been known as a potential way for treatment.Objectives: The goal of our study was assessment the relation between CHROMOGENIC IN SITU HYBRIDIZATION (CISH) and IMMUNOHISTOCHEMISTRY (IHC) methods in determining the best diagnostic method for gastric cancer.Methods: In this historical cohort study, 50 gastric cancer samples were analyzed by CISH and IHC. The relation between clinicalpathological parameters of HER2/NEU was also analyzed. Alive patients were followed from 2009 through 2012 for the main outcomes (mortality). The results of these two methods, in terms of sex, age, tumor size, grading, staging, tumor location, metaplasia, presence of necrosis and ulceration, vascular invasion, the TNM system, mucin or signet producing adenocarcinoma cells and patient survival rates were compared.Results: There was no significant difference between IHC and CISH regarding the sex, age, tumor size, grading, staging, tumor location, metaplasia, presence of necrosis and ulceration, vascular invasion, the TNM system, mucin or signet producing adenocarcinoma cells and patient survival rates. Comparison of TNMscores by these two methods showed no significant relationship between IHC and staging, but a statistically significant difference between CISH and different N staging, (P<0.05) was assessed.Conclusions: Comparison between IHC and CISH showed the only significant relationship between CISH and different N staging.Therefore, low amplified CISH was a better diagnostic method for gastric cancer, compared to low expression in IHC.

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APA: Copy

AMOUEIAN, SAKINEH, ATTARANZADEH, ARMIN, MONTAZER, MEHDI, AKHAVAN REZAYAT, ARASH, BEHFOROUZ, AMIR, & SOBHANI, FATEMEH. (2018). ASSESSMENT THE OF AMPLIFICATION HER-2/NEU GENE BY CHROMOGENIC IN SITU HYBRIDIZATION (CISH) COMPARED TO IMMUNOHISTOCHEMISTRY (IHC) METHOD IN GASTRIC CANCER. RAZAVI INTERNATIONAL JOURNAL OF MEDICINE, 6(1), 0-0. SID. https://sid.ir/paper/347689/en

Vancouver: Copy

AMOUEIAN SAKINEH, ATTARANZADEH ARMIN, MONTAZER MEHDI, AKHAVAN REZAYAT ARASH, BEHFOROUZ AMIR, SOBHANI FATEMEH. ASSESSMENT THE OF AMPLIFICATION HER-2/NEU GENE BY CHROMOGENIC IN SITU HYBRIDIZATION (CISH) COMPARED TO IMMUNOHISTOCHEMISTRY (IHC) METHOD IN GASTRIC CANCER. RAZAVI INTERNATIONAL JOURNAL OF MEDICINE[Internet]. 2018;6(1):0-0. Available from: https://sid.ir/paper/347689/en

IEEE: Copy

SAKINEH AMOUEIAN, ARMIN ATTARANZADEH, MEHDI MONTAZER, ARASH AKHAVAN REZAYAT, AMIR BEHFOROUZ, and FATEMEH SOBHANI, “ASSESSMENT THE OF AMPLIFICATION HER-2/NEU GENE BY CHROMOGENIC IN SITU HYBRIDIZATION (CISH) COMPARED TO IMMUNOHISTOCHEMISTRY (IHC) METHOD IN GASTRIC CANCER,” RAZAVI INTERNATIONAL JOURNAL OF MEDICINE, vol. 6, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/347689/en

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