مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

SUSCEPTIBILITY EVALUATION OF ASPERGILLUS FUMIGATUS TO SILVER NANOPARTICLES COMPARED WITH VORICONAZOLE

Pages

  20-23

Abstract

 Background: This study was performed to determine antifungal activity of SILVER NANOPARTICLES (nano-Ag) compared to voriconazole on clinical and standard strains of ASPERGILLUS FUMIGATUS.Materials and Methods: Inhibitory potency of nano-Ag was determined using microtiter broth dilution method. Susceptibility tests were performed against A. fumigatus isolated from BAL (bronchoalveolar lavage) of patients who suffered from respiratory problems and compared with the strain (ATCC: 204305) by broth dilution antifungal susceptibility test of filamentous fungi approved by the Clinical and Laboratory Standards Institute M38-A. In addition, CYTOTOXICITY effect of SILVER NANOPARTICLES was studied on epithelial cell line by MTT assay.Results: From 60 BAL samples the following strains were isolated; A. flavus (n=21), A. niger (n=3), and A. fumigatus (n=1). The minimum inhibitory concentration (MIC90) values of nano-Ag were 0.25 and 0.5 mg.mL-1 for standard strain and clinical isolates respectively. The Minimum Fungicidal Concentration (MFC) values of nano-Ag were 0.5 and 1 mg.mL-1 for standard strain and clinical isolates respectively.MIC90 values of voriconazole were 0.125 and 0.25 mg.mL-1 for standard strain and clinical isolate respectively. The MFC values of voriconazole were 0.25 and 0 mg.mL-1 for standard strain and clinical isolates respectively. SILVER NANOPARTICLES exhibited low CYTOTOXICITY in 0.25 mg.mL-1 concentration.Conclusion: Our results showed high antifungal activity of SILVER NANOPARTICLES against Aspergillus isolates. Furthermore, the availability of a wide form of nano-Ag structures can be considered as novel agents to decrease fungal burden in medical application.

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    APA: Copy

    BASHARDOUST, BAHAREH, ROUDBAR MOHAMMADI, SHAHLA, ROUDBARY, MARYAM, & NIKOOMANESH, FATEMEH. (2016). SUSCEPTIBILITY EVALUATION OF ASPERGILLUS FUMIGATUS TO SILVER NANOPARTICLES COMPARED WITH VORICONAZOLE. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), 2(3), 20-23. SID. https://sid.ir/paper/348184/en

    Vancouver: Copy

    BASHARDOUST BAHAREH, ROUDBAR MOHAMMADI SHAHLA, ROUDBARY MARYAM, NIKOOMANESH FATEMEH. SUSCEPTIBILITY EVALUATION OF ASPERGILLUS FUMIGATUS TO SILVER NANOPARTICLES COMPARED WITH VORICONAZOLE. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE)[Internet]. 2016;2(3):20-23. Available from: https://sid.ir/paper/348184/en

    IEEE: Copy

    BAHAREH BASHARDOUST, SHAHLA ROUDBAR MOHAMMADI, MARYAM ROUDBARY, and FATEMEH NIKOOMANESH, “SUSCEPTIBILITY EVALUATION OF ASPERGILLUS FUMIGATUS TO SILVER NANOPARTICLES COMPARED WITH VORICONAZOLE,” INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), vol. 2, no. 3, pp. 20–23, 2016, [Online]. Available: https://sid.ir/paper/348184/en

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