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Information Journal Paper

Title

Antibacterial Susceptibility Profiles and the Presence of Beta-Lactamase Resistance Genes and Virulence Factors in Pseudomonas aeruginosa Isolates

Pages

  131-137

Abstract

 Aims Pseudomonas aeruginosa is one of the major causes of nosocomial infections. This study aimed at investigating the antibacterial susceptibility and the prevalence of virulence and Resistance Genes of P. aeruginosa isolated from patients in Tehran, Iran. Materials & Methods In this cross-sectional study, 70 P. aeruginosa isolates from burn infection and cystic fibrosis patients were collected from Shahid Motahari Hospital and Pediatric Medical Center, Tehran, Iran during 2017-2018. Antibacterial susceptibility against eleven antibiotics was determined based on disk diffusion method. Isolates were, then, screened for the presence of virulence and Resistance Genes by Polymerase Chain Reaction (PCR). Findings The highest and lowest antibacterial resistance rates were against ampicillin and meropenem, respectively. The oprI and oprL genes were present in all P. aeruginosa isolates. The prevalence of toxA, exoS, exoU, exoT, and exoY genes in P. aeruginosa isolated from a total of 18 CF patients was 66. 6%, 66. 6%, 22. 2%, 72. 2%, and 77. 7%; and in isolates from a total of 52 burn patients was 84. 7%, 100%, 28. 8%, 73. 07%, and 64. 46%, respectively. VEB, PER, TEM, SHV, and CTX-M genes were found in 0. 0%, 0. 0%, 11. 1%, 16. 6%, and 5. 5% P. aeruginosa isolated from CF patients; and in 0. 0%, 1 1. 9%, 50 96. 1%, 88. 4%, and 40. 3%, P. aeruginosa isolated from burn patients, respectively. Conclusion Generally, selective pressure caused by extensive use of antibiotics can be conducive to the selection of MDR bacteria. Therefore, choosing suitable antibiotic based on precise antibiogram tests can prevent the increase of resistance in bacteria.

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    APA: Copy

    HAJIKHANI, S., DARBAN SAROKHALIL, D., & Babapour, E.. (2018). Antibacterial Susceptibility Profiles and the Presence of Beta-Lactamase Resistance Genes and Virulence Factors in Pseudomonas aeruginosa Isolates. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), 4(4), 131-137. SID. https://sid.ir/paper/348261/en

    Vancouver: Copy

    HAJIKHANI S., DARBAN SAROKHALIL D., Babapour E.. Antibacterial Susceptibility Profiles and the Presence of Beta-Lactamase Resistance Genes and Virulence Factors in Pseudomonas aeruginosa Isolates. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE)[Internet]. 2018;4(4):131-137. Available from: https://sid.ir/paper/348261/en

    IEEE: Copy

    S. HAJIKHANI, D. DARBAN SAROKHALIL, and E. Babapour, “Antibacterial Susceptibility Profiles and the Presence of Beta-Lactamase Resistance Genes and Virulence Factors in Pseudomonas aeruginosa Isolates,” INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), vol. 4, no. 4, pp. 131–137, 2018, [Online]. Available: https://sid.ir/paper/348261/en

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