TRANSCRIPTIONAL RESPONSES TO CINNAMALDEHYDE IN MYCOBACTERIUM TUBERCULOSIS

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Abkhoo Javad; JAHANI SOMAYEH; SHAFAGHAT MAHDIEH

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Journal Paper

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Journal: International Journal of Infection Year:2017 | Volume:4 | Issue:1 Page(s): 0-0

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Title

TRANSCRIPTIONAL RESPONSES TO CINNAMALDEHYDE IN MYCOBACTERIUM TUBERCULOSIS

Author(s)

Abkhoo Javad | JAHANI SOMAYEH | SHAFAGHAT MAHDIEH | Issue Writer Certificate

Keywords

ANTIMYCOBACTERIAL ACTIVITY

CINNAMALDEHYDE

MEDICINAL PLANT

MYCOBACTERIUM TUBERCULOSIS

Abstract

Background: Tuberculosis (TB) is an infectious disease caused by MYCOBACTERIUM TUBERCULOSIS.Objectives: Development of the drug resistance is becoming a threat to disease control, which underscores need for new agents targetingM. tuberculosis.Materials and Methods: In this study, analysis of gene expression was performed using real-time polymerase chain reaction (RTPCR).Results: Results of the current study showed that the minimum inhibitory concentration value of CINNAMALDEHYDE against M. tuberculosis was 200mg/mL. Moreover, RT-PCR data showed that a total of 25 genes were regulated by the CINNAMALDEHYDE. Of these, 12 genes were up-regulated, and 13 genes were down-regulated.Conclusions: CINNAMALDEHYDE is a pattern to expand the new anti-TB drugs, because the targets of the CINNAMALDEHYDE are different from those of anti-tubercular agents.

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APA: Copy

Abkhoo, Javad, JAHANI, SOMAYEH, & SHAFAGHAT, MAHDIEH. (2017). TRANSCRIPTIONAL RESPONSES TO CINNAMALDEHYDE IN MYCOBACTERIUM TUBERCULOSIS. INTERNATIONAL JOURNAL OF INFECTION, 4(1), 0-0. SID. https://sid.ir/paper/349180/en

Vancouver: Copy

Abkhoo Javad, JAHANI SOMAYEH, SHAFAGHAT MAHDIEH. TRANSCRIPTIONAL RESPONSES TO CINNAMALDEHYDE IN MYCOBACTERIUM TUBERCULOSIS. INTERNATIONAL JOURNAL OF INFECTION[Internet]. 2017;4(1):0-0. Available from: https://sid.ir/paper/349180/en

IEEE: Copy

Javad Abkhoo, SOMAYEH JAHANI, and MAHDIEH SHAFAGHAT, “TRANSCRIPTIONAL RESPONSES TO CINNAMALDEHYDE IN MYCOBACTERIUM TUBERCULOSIS,” INTERNATIONAL JOURNAL OF INFECTION, vol. 4, no. 1, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/349180/en

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