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Information Journal Paper

Title

THE EFFECT OF OMEGA FATTY ACIDS ON BCL-2 GENE EXPRESSION AND PROTEIN PRODUCTION IN CANCEROUS GASTRIC TISSUE

Pages

  24-28

Abstract

 Introduction: Gastric cancer is the fourth common cancer and the second leading cause of death from cancer worldwide. Omega FATTY ACIDS are a group of non-saturated FATTY ACIDS of long chains derive from linolenic, linoleic and oleic FATTY ACIDS. The current study aimed at examining the possible effects of oral administration of omega-3, -6 and -9 FATTY ACIDS on gastric cancer cell APOPTOSIS in patients with gastric adenocarcinoma via the evaluation of BCL2 gene and protein expression.Methods: In the present case-control study, a total of 34 patients with gastric cancer referring to the Endoscopy Clinic at Tabriz University of Medical Sciences were selected and divided into 2 groups (n = 17). In group 1, patients were treated by platinum drugs without any supplementation and in group 2, patients were treated by platinum drugs supplemented with omega-3, -6 and -9 FATTY ACIDS over 3 courses, which each lasted 3 weeks. After stomach biopsy, RNA extraction, cDNA synthesis and real-time polymerase chain reaction (RT-PCR) were performed.Results: The results showed that Bcl-2 gene and BCL2 protein expression in patients who received omega-3, -6 and -9 FATTY ACIDS with chemotherapy was lower than those of the ones who not received omega FATTY ACIDS. Also, there was a significant decrease in Bcl-2 gene expression (P<0.05).Conclusions: The oral administration of omega-3, -6 and -9 FATTY ACIDS with the chemotherapeutic drug cis-platinum in patients with gastric adenocarcinoma could decrease Bcl-2 gene expression and BCL2 protein production in the cancerous gastric tissue.

Cites

References

Cite

APA: Copy

GHANBARZADEH, HOMA DOKHT, & MOHADDES, SEYED MOJTABA. (2017). THE EFFECT OF OMEGA FATTY ACIDS ON BCL-2 GENE EXPRESSION AND PROTEIN PRODUCTION IN CANCEROUS GASTRIC TISSUE. MULTIDISCIPLINARY CANCER INVESTIGATION, 1(4), 24-28. SID. https://sid.ir/paper/349712/en

Vancouver: Copy

GHANBARZADEH HOMA DOKHT, MOHADDES SEYED MOJTABA. THE EFFECT OF OMEGA FATTY ACIDS ON BCL-2 GENE EXPRESSION AND PROTEIN PRODUCTION IN CANCEROUS GASTRIC TISSUE. MULTIDISCIPLINARY CANCER INVESTIGATION[Internet]. 2017;1(4):24-28. Available from: https://sid.ir/paper/349712/en

IEEE: Copy

HOMA DOKHT GHANBARZADEH, and SEYED MOJTABA MOHADDES, “THE EFFECT OF OMEGA FATTY ACIDS ON BCL-2 GENE EXPRESSION AND PROTEIN PRODUCTION IN CANCEROUS GASTRIC TISSUE,” MULTIDISCIPLINARY CANCER INVESTIGATION, vol. 1, no. 4, pp. 24–28, 2017, [Online]. Available: https://sid.ir/paper/349712/en

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