Strategies and Clinical Applications of Next Generation Sequencing

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KHORSHIDI SHOHREH; PALANGI ALIREZA

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Journal Paper

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Journal: Multidisciplinary Cancer Investigation Year:2018 | Volume:2 | Issue:4 Page(s): 5-15

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Information Journal Paper

Title

Strategies and Clinical Applications of Next Generation Sequencing

Author(s)

KHORSHIDI SHOHREH | PALANGI ALIREZA | Issue Writer Certificate

Keywords

High-Throughput

Nucleotide Sequencing

Whole Genome Sequencing

Whole Exome Sequencing

Clinical Application

Abstract

DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The High-Throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is similar to the traditional method, Sanger, which detects small DNA fragments by emitted signals at the time of synthesis of each fragment (from the DNA template), but the difference is that NGS can determine the massive simultaneous sequencing in a few days with high accuracy and the results are directly detected without the need for electrophoresis. In fact, NGS technology combines a variety of steps such as sample preparation, fragmentation of the sample of the studied genome, attachment of adapter to the ends of the fragments, imaging, and data analyses. In recent years, NGS technology continuously expanded the range of applications in different fields by reducing costs, increasing rates, and improving the quality of the data. The current review provided the potential applications of the NGS technology by emphasizing the diagnosis of the genetic diseases, identification of several types of cancers, prenatal screening, epigenetic modifications, personalized medicine, and identification of pathogens.

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APA: Copy

KHORSHIDI, SHOHREH, & PALANGI, ALIREZA. (2018). Strategies and Clinical Applications of Next Generation Sequencing. MULTIDISCIPLINARY CANCER INVESTIGATION, 2(4), 5-15. SID. https://sid.ir/paper/349714/en

Vancouver: Copy

KHORSHIDI SHOHREH, PALANGI ALIREZA. Strategies and Clinical Applications of Next Generation Sequencing. MULTIDISCIPLINARY CANCER INVESTIGATION[Internet]. 2018;2(4):5-15. Available from: https://sid.ir/paper/349714/en

IEEE: Copy

SHOHREH KHORSHIDI, and ALIREZA PALANGI, “Strategies and Clinical Applications of Next Generation Sequencing,” MULTIDISCIPLINARY CANCER INVESTIGATION, vol. 2, no. 4, pp. 5–15, 2018, [Online]. Available: https://sid.ir/paper/349714/en

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