Effect of topical Vancomycin on consolidation of sternum surgical fracture in open-heart surgery

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Alberto Machuca Maldonado Luis; Felix Campos Musquiz Luis; Andrea Vaca Brana Gloria; Sanchez Godínez Mario; Alejandro Castillo Lopez Cristian; Díaz Quiroz Guillermo; Vilchis Lopez Rafael; Luis Jose; Chimal Aceves

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Journal: JOURNAL OF CARDIO THORACIC MEDICINE Year:2019 | Volume:7 | Issue:4 Page(s): 523-529

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Title

Effect of topical Vancomycin on consolidation of sternum surgical fracture in open-heart surgery

Author(s)

Keywords

Open Heart Surgery

Surgical Fracture

Consolidation

Topical Vancomycin

Abstract

Introduction: The physiological process of sternum Surgical Fracture Consolidation in patients undergoing cardiac surgery could be prolonged by the invasion of gram-positive saprophytic bacteria which perpetuates the local inflammatory process despite the standardized aseptic and antiseptic measures in cardiac surgery. In this regard, the topical application of Vancomycin can exert a positive effect and prevent the perpetuation of the local inflammatory process by the elimination of these bacteria which in turn reduces bone Consolidation time. The purpose of the current study was to determine the effect of Topical Vancomycin on sternum Surgical Fracture Consolidation in patients undergoing to openheart surgery. Materials and Methods: Patients who underwent Open Heart Surgery were assigned into groups receiving the topical application of bone wax or Vancomycin mass in the spongy tissue exposed by surgical sternotomy, prior to sternal closure. The bone Consolidation processes were assessed by two expert radiologists with simple chest computed tomography (CT) in the postoperative period (4, 8, and 12 weeks). Results: The study was conducted on 55 patients in Vancomycin (n=33) and bone wax group (n=19). The computerized axial tomography (CAT) scan revealed a higher number of patients with early bone Consolidation (Medullar and bone continuity, and callus bone) in Vancomycin group, as compared to bone wax group (p values between 0. 004-0. 02 at 4 weeks and 0. 01-0. 06 at 8 weeks). However, no difference was observed at 12 weeks (P=0. 09-0. 11). Moreover, The magnitude effect of Topical Vancomycin was high (>90%) at 3, 8, and 12 weeks of follow up, compared to the patients who received bone wax (<90%). Conclusion: The Topical Vancomycin application had a positive effect on sternal Surgical Fracture and promotes an early bone Consolidation in patients undergoing open-heart surgery.

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APA: Copy

Alberto Machuca Maldonado, Luis, Felix Campos Musquiz, Luis, Andrea Vaca Brana, Gloria, Sanchez God?nez, Mario, Alejandro Castillo Lopez, Cristian, D?az Quiroz, Guillermo, Vilchis Lopez, Rafael, Luis, Jose, & Chimal, Aceves. (2019). Effect of topical Vancomycin on consolidation of sternum surgical fracture in open-heart surgery. JOURNAL OF CARDIO THORACIC MEDICINE, 7(4), 523-529. SID. https://sid.ir/paper/349899/en

Vancouver: Copy

Alberto Machuca Maldonado Luis, Felix Campos Musquiz Luis, Andrea Vaca Brana Gloria, Sanchez God?nez Mario, Alejandro Castillo Lopez Cristian, D?az Quiroz Guillermo, Vilchis Lopez Rafael, Luis Jose, Chimal Aceves. Effect of topical Vancomycin on consolidation of sternum surgical fracture in open-heart surgery. JOURNAL OF CARDIO THORACIC MEDICINE[Internet]. 2019;7(4):523-529. Available from: https://sid.ir/paper/349899/en

IEEE: Copy

Luis Alberto Machuca Maldonado, Luis Felix Campos Musquiz, Gloria Andrea Vaca Brana, Mario Sanchez God?nez, Cristian Alejandro Castillo Lopez, Guillermo D?az Quiroz, Rafael Vilchis Lopez, Jose Luis, and Aceves Chimal, “Effect of topical Vancomycin on consolidation of sternum surgical fracture in open-heart surgery,” JOURNAL OF CARDIO THORACIC MEDICINE, vol. 7, no. 4, pp. 523–529, 2019, [Online]. Available: https://sid.ir/paper/349899/en

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