High Serum Alpha-2-Macroglobulin Level in Patients with Osteonecrosis of the Femoral Head

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Naderi Ghale Noie Zari; HASSANI MOHAMMAD; KACHOOEI AMIR R.; Kerachian Mohammad A.

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Journal Paper

Paper Information

Journal: Archives of Bone and Joint Surgery Year:2018 | Volume:6 | Issue:3 Page(s): 219-224

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Title

High Serum Alpha-2-Macroglobulin Level in Patients with Osteonecrosis of the Femoral Head

Author(s)

Naderi Ghale Noie Zari | HASSANI MOHAMMAD | KACHOOEI AMIR R. | Kerachian Mohammad A. | Issue Writer Certificate

Keywords

Alpha-2-macroglobulin

Avascular necrosis of femoral head

Femur

Osteonecrosis

Abstract

Background: Diagnosis of Osteonecrosis of the femoral head (ONFH) is complicated due to the lack of reliable serum biomarkers. Up-regulation of Alpha-2-macroglobulin (A2M) gene has been reported in glucocorticoid-induced ANFH rat model. This study aimed to investigate whether the serum level of Alpha-2-macroglobulin (A2M) can be used for ONFH diagnosis. Methods: Serum protein capillary electrophoresis was performed on the sera of 36 ONFH patients. Also, human enzyme-linked immunosorbent assay was performed to evaluate the serum levels of A2M. Results: Alpha-2 subunit level, composed of Alpha-2-macroglobulin, ceruloplasmin and 2-2 haptoglobin phenotype, was increased significantly as compared to healthy subjects (P=0. 0001). Moreover, ELISA assay confirmed significant elevation in the A2M (P=0. 037). Conclusion: Our findings suggest that avascular necrotic Femur head presumably directly or indirectly elevates A2M in the bloodstream. Thus, serum level of A2M might be used as a reliable diagnostic tool in clinical practice.

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APA: Copy

Naderi Ghale Noie, Zari, HASSANI, MOHAMMAD, KACHOOEI, AMIR R., & Kerachian, Mohammad A.. (2018). High Serum Alpha-2-Macroglobulin Level in Patients with Osteonecrosis of the Femoral Head. THE ARCHIVES OF BONE AND JOINT SURGERY, 6(3), 219-224. SID. https://sid.ir/paper/350118/en

Vancouver: Copy

Naderi Ghale Noie Zari, HASSANI MOHAMMAD, KACHOOEI AMIR R., Kerachian Mohammad A.. High Serum Alpha-2-Macroglobulin Level in Patients with Osteonecrosis of the Femoral Head. THE ARCHIVES OF BONE AND JOINT SURGERY[Internet]. 2018;6(3):219-224. Available from: https://sid.ir/paper/350118/en

IEEE: Copy

Zari Naderi Ghale Noie, MOHAMMAD HASSANI, AMIR R. KACHOOEI, and Mohammad A. Kerachian, “High Serum Alpha-2-Macroglobulin Level in Patients with Osteonecrosis of the Femoral Head,” THE ARCHIVES OF BONE AND JOINT SURGERY, vol. 6, no. 3, pp. 219–224, 2018, [Online]. Available: https://sid.ir/paper/350118/en

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