Comparison of the Effect of Ciprofloxacin and Nalidixic Acid in the Infection of Different Parts of the Urinary Tract

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BINESH EHSAN; MIRZAII MEHDI; ASADI FATEME; ZOLFAGHARI POUNEH; NIKKHESLAT NASIM; SOHRABI MOHAMMAD BAGHER

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Journal: International Journal of Health Studies Year:2018 | Volume:4 | Issue:2 Page(s): 35-38

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Title

Comparison of the Effect of Ciprofloxacin and Nalidixic Acid in the Infection of Different Parts of the Urinary Tract

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Keywords

Escherichia coli

Ciprofloxacin

Nalidixic acid

Urinary tract infection

Abstract

Background: Urinary tract infection (UTI) is one of the most common bacterial infections. The most common cause is Escherichia coli. This research is done with the aim at compare effect of Ciprofloxacin with Nalidixic acid in the infection of different parts of the urinary tract. Methods: In this cross-sectional study, 130 patients with symptoms of the Urinary tract infection referred to Imam Hossain Hospital of Shahrood were studied. For the all patients, urine samples were collected by standard method and urine analysis and culture was performed. Then, positive culture samples were tested by antibiogram and the resistance rate for the two antibiotics Ciprofloxacin and Nalidixic acid and MBC and MIC was investigated. Results: Of the 130 patients with symptoms of UTI (fever, flank pain or tenderness and dysuria, urgency or frequency (84 patients had positive urine culture. Of all patients with positive urine, 31 cases had symptoms of pyelonephritis, 25 patients had symptoms of cystitis and 28 patients had symptoms of UTI. In antibiogram for positive urine samples, 21 pieces were resistant to Ciprofloxacin and 46 pieces were resistant to Nalidixic acid which significantly reduced resistance to Ciprofloxacin (P=0. 005). There was no significant difference between the two antibiotics in place of clinical symptoms and drug resistance. So there was no significant difference between the two MIC and MBC in place of clinical symptoms and drug resistance. Conclusions: This study showed that Ciprofloxacin is more effective in controlling infection of different parts of the urinary tract due to less drug resistance.

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APA: Copy

BINESH, EHSAN, MIRZAII, MEHDI, ASADI, FATEME, ZOLFAGHARI, POUNEH, NIKKHESLAT, NASIM, & SOHRABI, MOHAMMAD BAGHER. (2018). Comparison of the Effect of Ciprofloxacin and Nalidixic Acid in the Infection of Different Parts of the Urinary Tract. INTERNATIONAL JOURNAL OF HEALTH STUDIES, 4(2), 35-38. SID. https://sid.ir/paper/350334/en

Vancouver: Copy

BINESH EHSAN, MIRZAII MEHDI, ASADI FATEME, ZOLFAGHARI POUNEH, NIKKHESLAT NASIM, SOHRABI MOHAMMAD BAGHER. Comparison of the Effect of Ciprofloxacin and Nalidixic Acid in the Infection of Different Parts of the Urinary Tract. INTERNATIONAL JOURNAL OF HEALTH STUDIES[Internet]. 2018;4(2):35-38. Available from: https://sid.ir/paper/350334/en

IEEE: Copy

EHSAN BINESH, MEHDI MIRZAII, FATEME ASADI, POUNEH ZOLFAGHARI, NASIM NIKKHESLAT, and MOHAMMAD BAGHER SOHRABI, “Comparison of the Effect of Ciprofloxacin and Nalidixic Acid in the Infection of Different Parts of the Urinary Tract,” INTERNATIONAL JOURNAL OF HEALTH STUDIES, vol. 4, no. 2, pp. 35–38, 2018, [Online]. Available: https://sid.ir/paper/350334/en

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